Edward Gelmann, MD

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Professor, Medicine
Biography
Edward P. Gelmann, MD, is a professor of medicine in the Division of Hematology and Oncology at the University of Arizona College of Medicine – Tucson and holds the John Norton Endowed Chair for Prostate Cancer Research. Dr. Gelmann recently moved to Arizona from New York City where he had been a professor of medicine, pathology and cell biology as well as deputy director of the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center. He primarily cares for patients with genitourinary malignancies that include prostate, testicular, bladder and renal cell cancers. Dr. Gelmann serves as Editor-in-Chief of the journal Endocrine Oncology.
Cancer Focus
He continues his research on the molecular biology of prostate cancer. His laboratory has made major contributions to understanding of the genetic steps that transform a normal prostate cell to a cancer cell.
Selected Publications
Bowen, C., M. Shibata, H. Zhang, S. K. Bergren, M. M. Shen, and E. P. Gelmann, "CRISPR/Cas9-Mediated Point Mutation in Prolongs Protein Half-Life and Reverses Effects Allelic Loss.", Cancer Res, vol. 80, issue 21, pp. 4805-4814, 2020 Nov 01. PMCID: PMC7642110 PMID: 32943441
Bowen, C., M. C. Ostrowski, G. Leone, and E. P. Gelmann, "Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression.", Cancer Res, vol. 79, issue 16, pp. 4124-4134, 2019 08 15. PMCID: PMC6753942 PMID: 31213464
Bowen, C., T. Zheng, and E. P. Gelmann, "NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage.", Cancer Res, vol. 75, issue 13, pp. 2686-98, 2015 Jul 01. PMCID: PMC4511965 PMID: 25977336
Song, L-N., J. Silva, A. Koller, A. Rosenthal, E. I. Chen, and E. P. Gelmann, "The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase.", Mol Cancer Res, vol. 13, issue 5, pp. 913-22, 2015 May. PMCID: PMC4511920 PMID: 25777618
Bowen, C., J-H. Ju, J-H. Lee, T. T. Paull, and E. P. Gelmann, "Functional activation of ATM by the prostate cancer suppressor NKX3.1.", Cell Rep, vol. 4, issue 3, pp. 516-29, 2013 Aug 15. PMCID: PMC3838670 PMID: 23890999