Edward Gelmann, MD
Clinical and Translational Oncology Program
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Professor, Medicine
Biography
Edward P. Gelmann, MD, is a professor of medicine in the Division of Hematology and Oncology at the University of Arizona College of Medicine – Tucson and holds the John Norton Endowed Chair for Prostate Cancer Research. Dr. Gelmann recently moved to Arizona from New York City where he had been a professor of medicine, pathology and cell biology as well as deputy director of the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center. He primarily cares for patients with genitourinary malignancies that include prostate, testicular, bladder and renal cell cancers. Dr. Gelmann serves as Editor-in-Chief of the journal Endocrine Oncology.
Cancer Focus
He continues his research on the molecular biology of prostate cancer. His laboratory has made major contributions to understanding of the genetic steps that transform a normal prostate cell to a cancer cell.
Selected Publications
C. Bowen, Shibata, M., Zhang, H., Bergren, S. K., Shen, M. M., and Gelmann, E. P., “CRISPR/Cas9-Mediated Point Mutation in Prolongs Protein Half-Life and Reverses Effects Allelic Loss.”, Cancer Res, vol. 80, no. 21, pp. 4805-4814, 2020. PMCID: PMC7642110 PMID: 32943441
C. Bowen, Ostrowski, M. C., Leone, G., and Gelmann, E. P., “Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression.”, Cancer Res, vol. 79, no. 16, pp. 4124-4134, 2019. PMCID: PMC6753942 PMID: 31213464
L. - N. Song, Silva, J., Koller, A., Rosenthal, A., Chen, E. I., and Gelmann, E. P., “The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase.”, Mol Cancer Res, vol. 13, no. 5, pp. 913-22, 2015. PMCID: PMC4511920 PMID: 25777618
C. Bowen, Zheng, T., and Gelmann, E. P., “NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage.”, Cancer Res, vol. 75, no. 13, pp. 2686-98, 2015. PMCID: PMC4511965 PMID: 25977336
C. Bowen, Ju, J. - H., Lee, J. - H., Paull, T. T., and Gelmann, E. P., “Functional activation of ATM by the prostate cancer suppressor NKX3.1.”, Cell Rep, vol. 4, no. 3, pp. 516-29, 2013. PMCID: PMC3838670 PMID: 23890999