Casey E. Romanoski, PhD

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Associate Professor (Tenure), Cellular & Molecular Medicine
Biography
Dr. Romanoski received a B.A. in 2004 from the University of Arizona. She then received a Ph.D. from UCLA in Human Genetics in the laboratory of Dr. Jake Lusis. She then completed her postdoctoral research at UCSD in the laboratory of Dr. Christopher Glass. Throughout this training, she became very interested in the interdependence between genetic sequence and molecular traits, which is the foundation of her ongoing research. In 2016, Dr. Romanoski accepted a position as an Assistant Professor in the Department of Cellular and Molecular Medicine at the University of Arizona. Her research program uses experimental and computational approaches to better understand complex disease and human biology. She is currently Associate Professor of Cellular and Molecular Medicine.
Cancer Focus
Dr. Romanoski has ongoing projects to understand the cascade of molecular changes that occur consequent to stiff mechanical substrates with relevance to metastasis of breast cancer.
Selected Publications
Stolze, L. K., A. C. Conklin, M. B. Whalen, M. López Rodríguez, K. Õunap, I. Selvarajan, A. Toropainen, T. Örd, J. Li, A. Eshghi, et al., "Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits.", Am J Hum Genet, vol. 106, issue 6, pp. 748-763, 2020 06 04. PMCID: PMC7273528 PMID: 32442411
Hogan, N. T., M. B. Whalen, L. K. Stolze, N. K. Hadeli, M. T. Lam, J. R. Springstead, C. K. Glass, and C. E. Romanoski, "Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells.", Elife, vol. 6, 2017 06 06. PMCID: PMC5461113 PMID: 28585919
Romanoski, C. E., C. K. Glass, H. G. Stunnenberg, L. Wilson, and G. Almouzni, "Epigenomics: Roadmap for regulation.", Nature, vol. 518, issue 7539, pp. 314-6, 2015 Feb 19. PMID: 25693562
Heinz, S., C. E. Romanoski, C. Benner, K. A. Allison, M. U. Kaikkonen, L. D. Orozco, and C. K. Glass, "Effect of natural genetic variation on enhancer selection and function.", Nature, vol. 503, issue 7477, pp. 487-92, 2013 Nov 28. PMCID: PMC3994126 PMID: 24121437
Romanoski, C. E., S. Lee, M. J. Kim, L. Ingram-Drake, C. L. Plaisier, R. Yordanova, C. Tilford, B. Guan, A. He, P. S. Gargalovic, et al., "Systems genetics analysis of gene-by-environment interactions in human cells.", Am J Hum Genet, vol. 86, issue 3, pp. 399-410, 2010 Mar 12. PMCID: PMC2833388 PMID: 20170901