Reference
Lichauco K, Lee MS, Kuhns MS. 2018. Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed. Immunity. 49:786–788. doi:10.1016/j.immuni.2018.11.008.
Abstract
How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states.