Xinxin Ding, PhD

xding@pharmacy.arizona.edu

Links

Department Profile

NCBI Bibliography

PhD, Biological Chemistry, Medical School, University of Michigan, 1988
BS, Biology (Medical Physiology), Nanjing University (Nanjing, China), 1982

Cancer Focus

Lung cancer
Chemical carcinogenesis
Cancer prevention
Cancer therapy

Research Program Role

Cancer Biology Program

Display Name
Xinxin Ding, PhD

Publications

Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model.

Fan X, Ding X, Zhang Q-Y. 2020. Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model. Acta Pharm Sin B. 10:123–135. doi:10.1016/j.apsb.2019.12.002.

Proximal Tubular Vacuolization and Hypersensitivity to Drug-Induced Nephrotoxicity in Male Mice With Decreased Expression of the NADPH-Cytochrome P450 Reductase.

Ding L, Li L, Liu S, Bao X, Dickman KG, Sell SS, Mei C, Zhang Q-Y, Gu J, Ding X. 2020. Proximal Tubular Vacuolization and Hypersensitivity to Drug-Induced Nephrotoxicity in Male Mice With Decreased Expression of the NADPH-Cytochrome P450 Reductase. Toxicol Sci. 173:362–372. doi:10.1093/toxsci/kfz225.

Role of mouse cytochrome P450 enzymes of the CYP2ABFGS subfamilies in the induction of lung inflammation by cigarette smoke exposure.

Hartog M, Zhang Q-Y, Ding X. 2019 Aug. Role of mouse cytochrome P450 enzymes of the CYP2ABFGS subfamilies in the induction of lung inflammation by cigarette smoke exposure. Toxicol Sci. doi:10.1093/toxsci/kfz171.

Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using -Null and CYP2A13/2F1-Humanized Mice with Deficient Hepatic Cytochrome P450 Activity.

Kovalchuk N, Zhang Q-Y, Kelty J, Van Winkle L, Ding X. 2019. Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using -Null and CYP2A13/2F1-Humanized Mice with Deficient Hepatic Cytochrome P450 Activity. Drug Metab Dispos. 47:1469–1478. doi:10.1124/dmd.119.088930.

In Vivo SELEX of an Inhibitory NSCLC-Specific RNA Aptamer from PEGylated RNA Library.

Wang H, Zhang Y, Yang H, Qin M, Ding X, Liu R, Jiang Y. 2018. In Vivo SELEX of an Inhibitory NSCLC-Specific RNA Aptamer from PEGylated RNA Library. Mol Ther Nucleic Acids. 10:187–198. doi:10.1016/j.omtn.2017.12.003.

Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice.

Li L, Carratt S, Hartog M, Kovalchik N, Jia K, Wang Y, Zhang Q-Y, Edwards P, Van Winkle L, Ding X. 2017. Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice. Environ Health Perspect. 125:067004. doi:10.1289/EHP844.

Novel Transgenic Mouse Model for Studying Human Serum Albumin as a Biomarker of Carcinogenic Exposure.

Sheng J, Wang Y, Turesky RJ, Kluetzman K, Zhang Q-Y, Ding X. 2016. Novel Transgenic Mouse Model for Studying Human Serum Albumin as a Biomarker of Carcinogenic Exposure. Chem Res Toxicol. 29:797–809. doi:10.1021/acs.chemrestox.5b00529.

Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse.

Li L, Megaraj V, Wei Y, Ding X. 2014. Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse. Carcinogenesis. 35:2584–91. doi:10.1093/carcin/bgu182.

Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.

Megaraj V, Zhou X, Xie F, Liu Z, Yang W, Ding X. 2014. Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model. Carcinogenesis. 35:131–7. doi:10.1093/carcin/bgt269.