Xinxin Ding, PhD
Cancer Biology Program
Biography
PhD, Biological Chemistry, Medical School, University of Michigan, 1988
BS, Biology (Medical Physiology), Nanjing University (Nanjing, China), 1982
Cancer Focus
Lung cancer
Chemical carcinogenesis
Cancer prevention
Cancer therapy
Selected Publications
Ding, L., L. Li, S. Liu, X. Bao, K. G. Dickman, S. S. Sell, C. Mei, Q-Y. Zhang, J. Gu, and X. Ding, "Proximal Tubular Vacuolization and Hypersensitivity to Drug-Induced Nephrotoxicity in Male Mice With Decreased Expression of the NADPH-Cytochrome P450 Reductase.", Toxicol Sci, vol. 173, issue 2, pp. 362-372, 2020 02 01. PMID: 31693140
Fan, X., X. Ding, and Q-Y. Zhang, "Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model.", Acta Pharm Sin B, vol. 10, issue 1, pp. 123-135, 2020 Jan. PMCID: PMC6976992 PMID: 31993311
Hartog, M., Q-Y. Zhang, and X. Ding, "Role of mouse cytochrome P450 enzymes of the CYP2ABFGS subfamilies in the induction of lung inflammation by cigarette smoke exposure.", Toxicol Sci, 2019 Aug 06. PMCID: PMC6813748 PMID: 31388674
Kovalchuk, N., Q-Y. Zhang, J. Kelty, L. Van Winkle, and X. Ding, "Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using -Null and CYP2A13/2F1-Humanized Mice with Deficient Hepatic Cytochrome P450 Activity.", Drug Metab Dispos, vol. 47, issue 12, pp. 1469-1478, 2019 12. PMCID: PMC7042723 PMID: 31594800
Li, L., S. Carratt, M. Hartog, N. Kovalchik, K. Jia, Y. Wang, Q-Y. Zhang, P. Edwards, L. Van Winkle, and X. Ding, "Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice.", Environ Health Perspect, vol. 125, issue 6, pp. 067004, 2017 06 08. PMCID: PMC5743450 PMID: 28599267