Sara Centuori

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Shared Resource Director, Flow Cytometry
Flow Cytometry Shared Resource
Biography
Sara M. Centuori, PhD, is a Research Assistant Professor of Medicine, and Director of the Flow Cytometry and Immune Monitoring Shared Resource at the University of Arizona Cancer Center. She received her PhD from the University of Arizona in 2011 in the area of Cancer Biology with a predominant focus in the area of Tumor Immunology. She completed her postdoctoral training in 2018 also at the University of Arizona, where she received two T32 training awards, an R01 Minority Supplement, and actively served on the UArizona Cancer Center executive committee as postdoctoral representative. Her education and training resulted in unique expertise in Cancer Prevention and Immune Profiling of human biospecimens.
Cancer Focus
Dr. Centuori is a clinical and translational researcher focusing on the identification of novel immunomodulatory agents for the prevention and treatment of cancer. Her research interests focus on early stage clinical trials that examine the immuneprevention and immunotherapeutic properties of pharmaceutical and nutraceuticals agents with a special interest in obesity-associated breast and tobacco-related head and neck cancers. She is a recent recipient of an NCI-awarded Early Stage Investigator Research Supplement to Promote Diversity in Health-Related Research associated with the University of Arizona’s Cancer Prevention Clinical Trials Network (CP-CTNet). In this role she participates in the design, development, and execution early-stage cancer prevention trials, and emphasizes on driving minority recruitment to reduce health disparities in cancer prevention trials. She is also an active member of the Skin Cancer Prevention Program and the Head and Neck Translational Oncology group.
Selected Publications
Centuori, S. M., C. Caulin, and J. E. Bauman, "Precision and Immunoprevention Strategies for Tobacco-Related Head and Neck Cancer Chemoprevention.", Curr Treat Options Oncol, vol. 22, issue 6, pp. 52, 2021 May 15. PMCID: PMC8122210 PMID: 33991232
Centuori, S. M., C. J. Gomes, S. S. Kim, C. W. Putnam, B. T. Larsen, L. L. Garland, D. W. Mount, and J. D. Martinez, "Double-negative (CD27IgD) B cells are expanded in NSCLC and inversely correlate with affinity-matured B cell populations.", J Transl Med, vol. 16, issue 1, pp. 30, 2018 02 15. PMCID: PMC5815250 PMID: 29448960
Centuori, S. M., C. J. Gomes, J. Trujillo, J. Borg, J. Brownlee, C. W. Putnam, and J. D. Martinez, "Deoxycholic acid mediates non-canonical EGFR-MAPK activation through the induction of calcium signaling in colon cancer cells.", Biochim Biophys Acta, vol. 1861, issue 7, pp. 663-70, 2016 Jul. PMCID: PMC4900466 PMID: 27086143
Centuori, S. M., and J. D. Martinez, "Differential regulation of EGFR-MAPK signaling by deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) in colon cancer.", Dig Dis Sci, vol. 59, issue 10, pp. 2367-80, 2014 Oct. PMCID: PMC4163523 PMID: 25027205
Centuori, S. M., M. Trad, C. J. LaCasse, D. Alizadeh, C. B. Larmonier, N. T. Hanke, J. Kartchner, N. Janikashvili, B. Bonnotte, N. Larmonier, et al., "Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells.", J Leukoc Biol, vol. 92, issue 5, pp. 987-97, 2012 Nov. PMCID: PMC3476240 PMID: 22891289