Personalized treatment of cancer
Personalized treatment of cancer is rapidly becoming a standard practice. There are a number of factors that contribute to the uniqueness of a patient that include the individual’s genome, the genome and epigenome of the cancer, disease presentation, gender, exposures, lifestyle, microbiome, and other comorbidities. The identification of specific biomarkers, signaling pathways, immune cell signatures and genetic mutations within tumors underlies molecular targeted therapies and new insights into cancer treatment. The Tissue Acquisition and Cellular/Molecular Analysis Shared Resource (TACMASR) is integrated into the University of Arizona Cancer Center and provides support for studies related to advancing our understanding of the pathogenesis of cancers for the successful prevention, control and therapy of disease.
The TACMASR provides support and pathology-related services to UArizona Cancer Center and University of Arizona researchers on a fee-for-service basis. We strive to support investigator research endeavors through customized, cost-effective, and quality-controlled services including tissue acquisition, digital pathology, imaging and microscopy, histology and immunohistochemistry, and organoid culture.
This shared resource has a board-certified anatomic pathologist on staff with many years of clinical and experimental research experience.
TACMASR offers two primary types of services to UArizona Cancer Center and UArizona research investigators that include cellular and molecular analysis, and tissue acquisition and biobanking.
To build a project, get a quote, or order a service within iLab:
- Step 1: Select “About Our Core” to learn more about this Shared Resource.
- Step 2: Login or sign up for an iLab account at the University of Arizona. For login help, email iLabfirstname.lastname@example.org.
- Step 3: Once the login step is completed, obtaining prices, services and scheduling is available within the iLab system.
Please remember to acknowledge the Cancer Center Support Grant (P30 CA023074) when publishing manuscripts or abstracts that utilized the services of the University of Arizona Cancer Center’s Shared Resources and/or were derived from CCSG pilot funds. Suggested language: "Research reported in this [publication/press release] was supported by the National Cancer Institute of the National Institutes of Health under award number P30 CA023074.
Organoids can be established and expanded with high efficiency from primary patient tumor tissue and replicate much of the complexity of the tumor microenvironment. One application of organoid technology is to identify targeted cancer therapies and understand the pathogenesis of disease.
The Tissue Acquisition and Cellular/Molecular Analysis Shared Resource (TACMASR) is a multi-faceted research service facility that offers:
- Biorepository - procurement, storage, and retrieval of Cancer biorepository specimens as well as assistance with locating sample cohorts and access to other special collections. Contact Carole Kepler - email@example.com.
- Acquisition and preservation of tissues and body fluids
- Biospecimen banking and storage
- Routine Histology - paraffin & frozen samples, routine & special stains. Contact Maga Sanchez - firstname.lastname@example.org and Alexandra Jimenez - email@example.com.
- Immunostaining and in situ hybridization - Immunohistochemistry (IHC), In Situ Hybridization (ISH) using validated antibody staining protocols on automated platforms. Contact Maga Sanchez - firstname.lastname@example.org.
- Pathology - experimental advice, quality control, and scoring.
- Organoid Generation and Culture - Contact Yana Zavros (email@example.com).
These services are provided on a fee-for-service basis to members of the University of Arizona Cancer Center and to University of Arizona research investigators.
University of Arizona Cancer Center, Levy Building
Lab - Room 0917
Office – Room 0914
1515 N. Campbell, Tucson, AZ 85724