DISCOVERY (untargeted) Metabolomics and Lipidomics –

Analysis is performed on most sample types listed above.  The analysis is performed on a Thermo Vanquish Dual UPLC/Exploris 480 Orbi(producing HRAM spectra).   Chromatographic strategies include Reverse Phase and HILIC (With lipid specific chromatography for Lipidomics).  Sample preparation is available through the resource. Samples are processed utilizing Thermo Compound Discoverer and/or Lipid Search Software, statistical analysis utilizes R and Metaboanalyst.  As this is typically a tailored analysis please inquire with ACSR for a consultation to discuss projects.

* = available through Sub-core

** = 9-HOTrE, 13-HOTrE, 13-oxo-ODE, 9-oxo-ODE, 13-HODE, 9-HODE, 12(13)-EpOME, 9(10)-EpOME, EKODE, 12,13-DiHOME, 9,10-DiHOME, 15-deoxy-Prostaglandin J2, 15-HEPE, 8-HEPE, 12-HEPE, 5-HEPE, 17(18)-EpETE, 15-oxo-ETE, 14(15)-EpETE, 11(12)-EpETE, 8(9)-EpETE, 12-oxo-ETE, 5-oxo-ETE, 20-HETE, 15-HETE, 11-HETE, 8-HETE, 12-HETE, 9-HETE, 5-HETE, 14(15)-EET, 11(12)-EET, 8(9)-EET, 5(6)-EET, 15(S)-HETrE, Prostaglandin J2, Prostaglandin B2, 8,15-DiHETE, 6-trans-Leukotriene B4, 5,15-DiHETE, 17,18-DiHET, Leukotriene B4, 14,15-DiHETE, 5,6-DiHETE, 14,15-DiHET, Leukotriene B3, 11,12-DiHET, 8,9-DiHET, 5,6-DiHET, 17-HDHA, 19(20)-EpDPA, 16(17)-EpDPA, 13(14)-EpDPA, 10(11)-EpDPA, 7(8)-EpDPA, Prostaglandin E3, Prostaglandin D3, 20-OH-Leukotriene B4, Prostaglandin E2, Prostaglandin D2, Lipoxin A4, Prostaglandin F2a, Prostaglandin E1, Prostaglandin D1, 19,20-DiHDPE, 20-COOH-LTB4, 6-keto-PGF1a, TXB2, Resolvin D1

*** = 3-hydroxyanthranilic acid, quinolinic acid, anthranilic acid, L-tryptophan, L-kynurenine, kynurenic acid, 3-hydroxykynurenine, cinnabarinic acid, xanthurenic acid, N-formylkynurenine, picolinic acid, 5-hydroxytryptophan, serotonin, melatonin, tryptamine, glutamic acid, dopamine
 

Contact

UACC-ACSR@uacc.arizona.edu

Potential users, especially first-time users, are encouraged to personally contact ACSR service personnel for instructions on how to access all the services of the Analytical Chemistry Shared Resource. 

Please contact Dr. Snider by phone or email. After a short discussion about your project, the service request form can be submitted to the ACSR and a realistic timeline can be projected.

All University of Arizona Cancer Center members have access to the Analytical Chemistry Shared Resource. The service is provided according to the following University of Arizona Cancer Center priority guidelines

1. University of Arizona Cancer Center members with peer-reviewed extramural funding;
2. New University of Arizona Cancer Center investigators with University of Arizona Cancer Center pilot project or developmental funding;
3. University of Arizona Cancer Center members with other funding sources;
4. Peer-reviewed, funded non-members at University of Arizona if sufficient time/resources are available to accommodate requested service.