Timothy W Secomb, PhD
Clinical and Translational Oncology Program
Biography
Trained as an applied mathematician, Dr. Secomb has been conducting research for more than 35 years focusing on the microcirculation, the network of extremely small blood vessels that supplies oxygen and nutrients to all parts of our tissues, including tumors. He uses mathematical and computational approaches to study blood flow and mass transport in the microcirculation, structural adaptation of vessels and angiogenesis and local regulation of blood flow in both the systemic and pulmonary circulations. Other areas of research include models for the pharmacodynamics of cancer drugs, and the mechanics of the left ventricle. He has published more than 180 peer-reviewed journal articles, obtaining more than 9,300 citations.
Cancer Focus
Theoretical modeling of tumor mass transport, pharmacodynamics, vascular adaptation and angiogenesis.
Selected Publications
Williams, K. S., T. W. Secomb, and A. W. El-Kareh, "Additive Damage Models for Cellular Pharmacodynamics of Radiation-Chemotherapy Combinations.", Bull Math Biol, vol. 80, issue 5, pp. 1236-1258, 2018 05. PMID: 28849417
Dewhirst, M. W., and T. W. Secomb, "Transport of drugs from blood vessels to tumour tissue.", Nat Rev Cancer, vol. 17, issue 12, pp. 738-750, 2017 12. PMID: 29123246
Pries, A. R., and T. W. Secomb, "Making microvascular networks work: angiogenesis, remodeling, and pruning.", Physiology (Bethesda), vol. 29, issue 6, pp. 446-55, 2014 Nov. PMCID: PMC4280154 PMID: 25362638
Secomb, T. W., J. P. Alberding, R. Hsu, M. W. Dewhirst, and A. R. Pries, "Angiogenesis: an adaptive dynamic biological patterning problem.", PLoS Comput Biol, vol. 9, issue 3, pp. e1002983, 2013. PMCID: PMC3605064 PMID: 23555218
Pries, A. R., M. Höpfner, F. le Noble, M. W. Dewhirst, and T. W. Secomb, "The shunt problem: control of functional shunting in normal and tumour vasculature.", Nat Rev Cancer, vol. 10, issue 8, pp. 587-93, 2010 Aug. PMCID: PMC3109666 PMID: 20631803