Terry O Matsunaga, PharmD, PhD
Biography
Dr. Matsunaga received his AB degree in Biochemistry from the University of California at Berkeley, followed by a Pharm.D in Clinical Pharmacy at the University of California San Francisco (UCSF). Following a year of clinical training as a resident at the University of Michigan, he returned to UCSF where he received his Ph.D. in Pharmaceutical Chemistry under the mentorship of George L. Kenyon. From 1986 - 1992, he was a NIDA post-doctoral fellow in the laboratory of Professor Victor J. Hruby. Since 2010, he has chaired the Steering Committee for the NHLBI SMARTT (Science Moving Towards Research Translation and Therapy) Program.
Cancer Focus
Dr. Matsunaga studies contrast enhanced ultrasound (CEUS) with a focus on micro bubble development and phase-change per fluorocarbon contrast agents for vascular and extravascular imaging. His current research emphasizes the potential for early detection of breast cancer.
Selected Publications
Cromey, B., A. McDaniel, T. Matsunaga, J. Vagner, K. Quoc Kieu, and B. Banerjee, "Pancreatic cancer cell detection by targeted lipid microbubbles and multiphoton imaging.", J Biomed Opt, vol. 23, issue 4, pp. 1-8, 2018 Apr. PMID: 29633610
Hadinger, K. P., J. P. Marshalek, P. S. Sheeran, P. A. Dayton, and T. O. Matsunaga, "Optimization of Phase-Change Contrast Agents for Targeting MDA-MB-231 Breast Cancer Cells.", Ultrasound Med Biol, vol. 44, issue 12, pp. 2728-2738, 2018 12. PMCID: PMC6215505 PMID: 30228045
Harpel, K., R. Dawson Baker, B. Amirsolaimani, S. Mehravar, J. Vagner, T. O. Matsunaga, B. Banerjee, and K. Kieu, "Imaging of targeted lipid microbubbles to detect cancer cells using third harmonic generation microscopy.", Biomed Opt Express, vol. 7, issue 7, pp. 2849-60, 2016 Jul 01. PMCID: PMC4948635 PMID: 27446711
Marshalek, J. P., P. S. Sheeran, P. Ingram, P. A. Dayton, R. S. Witte, and T. O. Matsunaga, "Intracellular delivery and ultrasonic activation of folate receptor-targeted phase-change contrast agents in breast cancer cells in vitro.", J Control Release, vol. 243, pp. 69-77, 2016 12 10. PMCID: PMC5191940 PMID: 27686582
Sheeran, P. S., S. Luois, P. A. Dayton, and T. O. Matsunaga, "Formulation and acoustic studies of a new phase-shift agent for diagnostic and therapeutic ultrasound.", Langmuir, vol. 27, issue 17, pp. 10412-20, 2011 Sep 06. PMCID: PMC3164903 PMID: 21744860