Rui Chang, PhD

-
Associate Professor, Neurology
Biography
Rui Chang earned his B.Sc. in Electrical Engineering from Beijing University of Technology and M.Sc in Communication Engineering from Technical University of Munich (TUM), Germany and obtained Ph.D in Computer Science with focus on machine learning from TUM. He completed postdoctoral training in computational biology at University of California, San Diego. He joined Icahn School of Medicine at Mount Sinai as an Assistant Professor in 2011. In 2018, he moved to University of Arizona as Associate Professor in the department of Neurology and the associated director for computational systems biology in The Center of Innovations in Brain Sciences. He is PI of Computational Biology lab in neurodegenerative diseases and cancer.
Cancer Focus
My researches in cancer investigate the molecular mechanisms of immune response in various tumors and interactions between tumor and microenvironment especially immune systems by leveraging computational models. The final goal of my research is to discover novel and adjuvants immunotherapy for cancer.
Selected Publications
Carcamo-Orive, I., M. Y. R. Henrion, K. Zhu, N. D. Beckmann, P. Cundiff, S. Moein, Z. Zhang, M. Alamprese, S. L. D'Souza, M. Wabitsch, et al., "Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness.", PLoS Comput Biol, vol. 16, issue 12, pp. e1008491, 2020 12. PMCID: PMC7790417 PMID: 33362275
Gartrell, R. D., D. K. Marks, E. M. Rizk, M. Bogardus, C. L. Gérard, L. W. Barker, Y. Fu, C. L. Esancy, G. Li, J. Ji, et al., "Validation of Melanoma Immune Profile (MIP), a Prognostic Immune Gene Prediction Score for Stage II-III Melanoma.", Clin Cancer Res, vol. 25, issue 8, pp. 2494-2502, 2019 04 15. PMCID: PMC6594682 PMID: 30647081
Petyuk, V. A., R. Chang, M. Ramirez-Restrepo, N. D. Beckmann, M. Y. R. Henrion, P. D. Piehowski, K. Zhu, S. Wang, J. Clarke, M. J. Huentelman, et al., "The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target.", Brain, vol. 141, issue 9, pp. 2721-2739, 2018 09 01. PMCID: PMC6136080 PMID: 30137212
Carcamo-Orive, I., G. E. Hoffman, P. Cundiff, N. D. Beckmann, S. L. D'Souza, J. W. Knowles, A. Patel, D. Papatsenko, F. Abbasi, G. M. Reaven, et al., "Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.", Cell Stem Cell, vol. 20, issue 4, pp. 518-532.e9, 2017 04 06. PMCID: PMC5384872 PMID: 28017796
Sivendran, S., R. Chang, L. Pham, R. G. Phelps, S. T. Harcharik, L. D. Hall, S. G. Bernardo, M. M. Moskalenko, M. Sivendran, Y. Fu, et al., "Dissection of immune gene networks in primary melanoma tumors critical for antitumor surveillance of patients with stage II-III resectable disease.", J Invest Dermatol, vol. 134, issue 8, pp. 2202-2211, 2014 Aug. PMCID: PMC4291112 PMID: 24522433