Ronald M Lynch, PhD
Associate Professor, Pharmacology
Professor, BIO5 Institute
Director, Aribi Institute
Professor, Biomedical Engineering
Professor, Physiological Sciences - GIDP
Associate Director, Shared Resources
Dr. Lynch received a Ph.D. in Physiology and Biophysics from the University of Cincinnati (1984) followed by postdoctoral training at the NIH in Cardiac Energetics. In 1987 Dr. Lynch moved to the Biomedical Imaging Group at the University of Massachusetts Medical Center then joined the University of Arizona in 1990 where he is Professor of Physiology with a joint appointments in Pharmacology and Biomedical Engineering, and is the Director of the Arizona Research Institute for Biomedical Imaging. Dr. Lynch is a member of the American Diabetes Association Grant Review Committee and is a Councilor for the American Physiological Society with service on other national grant and journal review committees.
Research in the Lynch lab is focused on the coupling of metabolism and second messenger signaling in nutrient sensing and cancer cells. Analyses of subcellular protein distributions, second messenger signaling, and ligand binding is performed using state of the art microscopy and analysis approaches. For the past 30 years, we have developed unique microscopic imaging and spectroscopy tools to study cell and tissue function, as well as screening assays for cell signaling and ligand binding.
Elshan, N. G. R. Dayan, T. Jayasundera, B. L. Anglin, C. S. Weber, R. M. Lynch, and E. A. Mash, "Trigonal scaffolds for multivalent targeting of melanocortin receptors.", Org Biomol Chem, vol. 13, issue 6, pp. 1778-91, 2015 Feb 14. PMCID: PMC4780440 PMID: 25502141
Escalante, A. M., R. T. McGrath, M. R. Karolak, R. T. Dorr, R. M. Lynch, and T. H. Landowski, "Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo.", Cancer Chemother Pharmacol, vol. 71, issue 6, pp. 1567-76, 2013 Jun. PMCID: PMC3669633 PMID: 23572175
Brabez, N., R. M. Lynch, L. Xu, R. J. Gillies, G. Chassaing, S. Lavielle, and V. J. Hruby, "Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: tools toward melanoma diagnosis and treatment.", J Med Chem, vol. 54, issue 20, pp. 7375-84, 2011 Oct 27. PMCID: PMC3521580 PMID: 21928837
Landowski, T. H., C. J. Megli, K. D. Nullmeyer, R. M. Lynch, and R. T. Dorr, "Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of Velcade (PS-341/bortezomib) cytotoxicity in myeloma cell lines.", Cancer Res, vol. 65, issue 9, pp. 3828-36, 2005 May 01. PMID: 15867381
Martinez-Zaguilan, R., R. M. Lynch, G. M. Martinez, and R. J. Gillies, "Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells.", Am J Physiol, vol. 265, issue 4 Pt 1, pp. C1015-29, 1993 Oct. PMID: 8238296