Raymond B Runyan, PhD
Cancer Biology Program
Biography
B.A. (Biology) Macalester College, 1972; M.S. (Genetics) Florida State University, 1976; PhD (Cell Biology and Anatomy) Texas Tech University Health Sciences Center, 1983: Postdoctoral Fellow (Cell Biology), University of Connecticut Health Center,1993-84; Research Investigator (Biochemistry and Molecular Biology), University of Texas M.D. Anderson Cancer Center, 1984-1986. Faculty, Assistant & Associate Professor, Cell Biology and Anatomy, University of Iowa 1986-1992; Associate & Full Professor, Cellular and Molecular Medicine, University of Arizona, 1992-present.
Cancer Focus
Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells change shape and become invasive. This is a normal process in the embryo that produces 3-dimensional structure. EMT is re-utilized in the pathologies of cancer metastasis and organ fibrosis in the adult. My lab has studied normal EMT during heart valve development for decades. We were the first to find that EMT is a transcriptionally regulated process mediated by members of the Transforming Growth Factor Beta (TGFb) family. As metastasis is a TGFb-regulated process in cancer, we explore the common elements of EMT between embryonic development and the mechanisms of cell invasion in both glioblastoma and colon cancer.
Selected Publications
V. N. Nfonsam, Nfonsam, L. E., Chen, D., Omesiete, P. N., Cruz, A., Runyan, R. B., and Jandova, J., “COMP Gene Coexpresses With EMT Genes and Is Associated With Poor Survival in Colon Cancer Patients.”, J Surg Res, vol. 233, pp. 297-303, 2019. PMID: 30502262
A. L. P. Tavares, Brown, J. A., Ulrich, E. C., Dvorak, K., and Runyan, R. B., “Runx2-I is an Early Regulator of Epithelial-Mesenchymal Cell Transition in the Chick Embryo.”, Dev Dyn, vol. 247, no. 3, pp. 542-554, 2018. PMCID: PMC5736463 PMID: 28631378
A. Lencinas, Chhun, D. C., Dan, K. P., Ross, K. D., Hoover, E. A., Antin, P. B., and Runyan, R. B., “Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart.”, Dis Model Mech, vol. 6, no. 3, pp. 632-42, 2013. PMCID: PMC3634647 PMID: 23264563
C. B. Brown, Boyer, A. S., Runyan, R. B., and Barnett, J. V., “Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart.”, Science, vol. 283, no. 5410, pp. 2080-2, 1999. PMID: 10092230
R. B. Runyan and Markwald, R. R., “Invasion of mesenchyme into three-dimensional collagen gels: a regional and temporal analysis of interaction in embryonic heart tissue.”, Dev Biol, vol. 95, no. 1, pp. 108-14, 1983. PMID: 6825921