Rachna T Shroff, MD, MS

Medical Director, Clinical Trials Office
Chief, Section of GI Medical Oncology
Director, Arizona Clinical Trials Network
Clinical and Translational Oncology Program


Rachna T. Shroff, MD, MS, is an Associate Professor of Medicine and Chief of GI Medical Oncology as well as Leader of the Gastrointestinal Clinical Research Team at the University of Arizona Cancer Center. She is the Director of the UArizona Cancer Center Clinical Trials Office as well as the Director of the Arizona Clinical Trials Network (ACTN), and Vice Chair of Clinical Research for the Department of Medicine. She came to the Cancer Center from MD Anderson Cancer Center in Houston, TX where she served as faculty from 2010-2018 after completing her medical oncology fellowship there.

Dr. Shroff is a clinical and translational investigator focused on developing novel therapies for pancreatic and biliary cancers. She holds multiple positions nationally due to her expertise in these areas, including serving as the Hepatobiliary subcommittee Co-Chair for the Southwest Oncology Group (SWOG) and as a Program Committee member for GI ASCO. She also is a member of the Scientific and Medical Advisory Board for the Cholangiocarcinoma Foundation. Dr. Shroff has led numerous clinical trials focusing on pancreaticobiliary tumors and is the national PI for SWOG 1815 which is investigating a triplet chemotherapy regimen as a potential new standard of care for biliary cancers. This is based on a phase 2 study she led that is now published in JAMA Oncology. Dr. Shroff has been invited to speak at national and international meetings on topics related to targeted therapies for pancreatic and biliary cancers and has numerous peer-reviewed publications in this area.

Cancer Focus

Dr. Shroff has focused her career on clinical and translational research in GI malignancies. She has been the Principal Investigator on a number of trials in this space. She has established herself a leading expert in pancreatic and biliary cancer and is the national P.I. on a SWOG phase III study in this disease. Dr. Shroff has authored multiple peer-reviewed publications and she has been invited to give platform presentations on pancreatic and biliary cancers across the world. In addition, Dr. Shroff is the leader of the Gastrointestinal Oncology Clinical Research Team at University of Arizona Cancer Center. She also serves as the Medical Director of the Clinical Trials Office.