Pawel R Kiela, DVM, PhD

Professor, Pediatrics

pkiela@peds.arizona.edu

Links

1994 DVM, Warsaw University of Life Sciences, School of Veterinary Medicine, Warsaw, Poland
1996 Ph.D., Warsaw University of Life Sciences, School of Veterinary Medicine, Warsaw, Poland and University of Lund, Lund, Sweden
1997 –1999 Research Associate, UA Department of Pediatrics
2000 Research Assistant Scientist, UA Department of Pediatrics,
2001-2005 Research Assistant Professor, UA Department of Pediatrics
2005-2018 Associate Professor, UA Department of Pediatrics, tenured in June 2012
2007 – present Associate Professor, Joint appointment with the UA Department of Immunobiology
2018 – present Professor, PANDA Endowed Professor in Autoimmune Disease Research, Director of the Gastroenterology Research Laboratories, UA Department of Pediatrics

Cancer Focus

My lab is interested in the pathogenesis of inflammatory bowel diseases (IBD) and inflammation-associated colorectal cancer. Our work is focused on the innate immune responses in the gastrointestinal mucosa, gut microbiota, and the gut epithelial cell biology as the interface between the microbiota and the mucosal immune system.

Research Program Role

Cancer Biology Program

Display Name

Pawel R Kiela, DVM, PhD

Publications

Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T-Cell-Induced, and Infectious Colitis in Mice.

Jamwal DR, Laubitz D, Harrison CA, Figliuolo da Paz V, Cox CM, Wong R, Midura-Kiela M, Gurney MA, Besselsen DG, Setty P, et al. 2020. Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T-Cell-Induced, and Infectious Colitis in Mice. Gastroenterology. 159:1342–1356.e6. doi:10.1053/j.gastro.2020.06.049.

Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells.

Figliuolo da Paz V, Jamwal DR, Gurney M, Midura-Kiela M, Harrison CA, Cox C, Wilson JM, Ghishan FK, Kiela PR. 2019. Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells. Front Immunol. 10:304. doi:10.3389/fimmu.2019.00304.

Sexual Dimorphism in the Response to Broad-spectrum Antibiotics During T Cell-mediated Colitis.

Harrison CA, Laubitz D, Midura-Kiela MT, Jamwal DR, Besselsen DG, Ghishan FK, Kiela PR. 2019. Sexual Dimorphism in the Response to Broad-spectrum Antibiotics During T Cell-mediated Colitis. J Crohns Colitis. 13:115–126. doi:10.1093/ecco-jcc/jjy144.

Microbial dysbiosis associated with impaired intestinal Na/H exchange accelerates and exacerbates colitis in ex-germ free mice.

Harrison CA, Laubitz D, Ohland CL, Midura-Kiela MT, Patil K, Besselsen DG, Jamwal DR, Jobin C, Ghishan FK, Kiela PR. 2018. Microbial dysbiosis associated with impaired intestinal Na/H exchange accelerates and exacerbates colitis in ex-germ free mice. Mucosal Immunol. 11:1329–1341. doi:10.1038/s41385-018-0035-2.

The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention.

McFadden R-MT, Larmonier CB, Shehab KW, Midura-Kiela M, Ramalingam R, Harrison CA, Besselsen DG, Chase JH, Caporaso JG, Jobin C, et al. 2015. The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention. Inflamm Bowel Dis. 21:2483–94. doi:10.1097/MIB.0000000000000522.

Gut microbial dysbiosis may predict diarrhea and fatigue in patients undergoing pelvic cancer radiotherapy: a pilot study.

Wang A, Ling Z, Yang Z, Kiela PR, Wang T, Wang C, Cao L, Geng F, Shen M, Ran X, et al. 2015. Gut microbial dysbiosis may predict diarrhea and fatigue in patients undergoing pelvic cancer radiotherapy: a pilot study. PLoS One. 10:e0126312. doi:10.1371/journal.pone.0126312.

Pawel R Kiela, DVM, PhD

Links

Cancer Focus

Display Name Pawel R Kiela, DVM, PhD

Publications

Display Name

Pawel R Kiela, DVM, PhD