Michael T Marty, PhD

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Michael Marty, Ph.D., is an Assistant Professor of Chemistry & Biochemistry at The University of Arizona. Dr. Marty earned his B.A. in chemistry and mathematics at St. Olaf College in 2010, graduating summa cum laude and Phi Beta Kappa. He completed his Ph.D. in chemistry as a Springborn Fellow at the University of Illinois Urbana-Champaign in 2013 followed by postdoctoral research at the University of Oxford until joining the faculty in 2016. He has been awarded the ASMS Research Award, the Bisgrove Scholar Award, and the NIH MIRA award. His research applies lipoprotein nanodiscs with mass spectrometry to study membrane proteins, antimicrobial peptides, and their interactions with lipid bilayers.

Cancer Focus

Prof. Marty’s research centers on developing new technologies to study interactions at biological membranes, with a special focus on combining lipoprotein nanodiscs and native mass spectrometry. One aspect of his research focuses on characterizing membrane protein-protein and membrane protein-lipid interactions. Membrane proteins are important drug targets, and the Marty lab seeks to understand how lipids influence membrane proteins important in cancer. The second aspect of Prof. Marty’s research focuses on assembly of antimicrobial peptide complexes, which also show anticancer activity. By characterizing the biophysics of peptide interactions with and within lipid bilayers, they seek to shed light on the mechanisms of anticancer peptide toxicity and selectivity.

Research Program Role

Clinical and Translational Oncology Program

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Michael T Marty, PhD

Publications

Walker LR, Marty MT. 2020. Revealing the Specificity of a Range of Antimicrobial Peptides in Lipid Nanodiscs by Native Mass Spectrometry. Biochemistry. 59:2135–2142. doi:10.1021/acs.biochem.0c00335.

Zhang G, Keener JE, Marty MT. 2020. Measuring Remodeling of the Lipid Environment Surrounding Membrane Proteins with Lipid Exchange and Native Mass Spectrometry. Anal Chem. 92:5666–5669. doi:10.1021/acs.analchem.0c00786.

Kostelic MM, Ryan AM, Reid DJ, Noun JM, Marty MT. 2019. Expanding the Types of Lipids Amenable to Native Mass Spectrometry of Lipoprotein Complexes. J Am Soc Mass Spectrom. 30:1416–1425. doi:10.1007/s13361-019-02174-x.

Reid DJ, Diesing JM, Miller MA, Perry SM, Wales JA, Montfort WR, Marty MT. 2019. MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra. J Am Soc Mass Spectrom. 30:118–127. doi:10.1007/s13361-018-1951-9.

Walker LR, Marzluff EM, Townsend JA, Resager WC, Marty MT. 2019. Native Mass Spectrometry of Antimicrobial Peptides in Lipid Nanodiscs Elucidates Complex Assembly. Anal Chem. 91:9284–9291. doi:10.1021/acs.analchem.9b02261.

Keener JE, Zambrano DE, Zhang G, Zak CK, Reid DJ, Deodhar BS, Pemberton JE, Prell JS, Marty MT. 2018 Dec. Chemical additives enable native mass spectrometry measurement of membrane protein oligomeric state within intact nanodiscs. J Am Chem Soc. doi:10.1021/jacs.8b11529.

Reid DJ, Keener JE, Wheeler AP, Zambrano DE, Diesing JM, Reinhardt-Szyba M, Makarov A, Marty MT. 2017. Engineering Nanodisc Scaffold Proteins for Native Mass Spectrometry. Anal Chem. 89:11189–11192. doi:10.1021/acs.analchem.7b03569.

Marty MT, Hoi KK, Robinson CV. 2016. Interfacing Membrane Mimetics with Mass Spectrometry. Acc Chem Res. 49:2459–2467. doi:10.1021/acs.accounts.6b00379.

Michael T Marty, PhD

Links

Cancer Focus

Display NameMichael T Marty, PhD

Publications

Display Name
Michael T Marty, PhD