Michael T Marty, PhD
Clinical and Translational Oncology Program
Biography
Michael Marty, Ph.D., is an Assistant Professor of Chemistry & Biochemistry at The University of Arizona. Dr. Marty earned his B.A. in chemistry and mathematics at St. Olaf College in 2010, graduating summa cum laude and Phi Beta Kappa. He completed his Ph.D. in chemistry as a Springborn Fellow at the University of Illinois Urbana-Champaign in 2013 followed by postdoctoral research at the University of Oxford until joining the faculty in 2016. He has been awarded the ASMS Research Award, the Bisgrove Scholar Award, and the NIH MIRA award. His research applies lipoprotein nanodiscs with mass spectrometry to study membrane proteins, antimicrobial peptides, and their interactions with lipid bilayers.
Cancer Focus
Prof. Marty’s research centers on developing new technologies to study interactions at biological membranes, with a special focus on combining lipoprotein nanodiscs and native mass spectrometry. One aspect of his research focuses on characterizing membrane protein-protein and membrane protein-lipid interactions. Membrane proteins are important drug targets, and the Marty lab seeks to understand how lipids influence membrane proteins important in cancer. The second aspect of Prof. Marty’s research focuses on assembly of antimicrobial peptide complexes, which also show anticancer activity. By characterizing the biophysics of peptide interactions with and within lipid bilayers, they seek to shed light on the mechanisms of anticancer peptide toxicity and selectivity.
Selected Publications
Zhang, G., J. E. Keener, and M. T. Marty, "Measuring Remodeling of the Lipid Environment Surrounding Membrane Proteins with Lipid Exchange and Native Mass Spectrometry.", Anal Chem, vol. 92, issue 8, pp. 5666-5669, 2020 04 21. PMCID: PMC7204402 PMID: 32250609
Walker, L. R., and M. T. Marty, "Revealing the Specificity of a Range of Antimicrobial Peptides in Lipid Nanodiscs by Native Mass Spectrometry.", Biochemistry, vol. 59, issue 23, pp. 2135-2142, 2020 Jun 16. PMCID: PMC7307383 PMID: 32452672
Reid, D. J., J. M. Diesing, M. A. Miller, S. M. Perry, J. A. Wales, W. R. Montfort, and M. T. Marty, "MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra.", J Am Soc Mass Spectrom, vol. 30, issue 1, pp. 118-127, 2019 Jan. PMCID: PMC6192864 PMID: 29667162
Walker, L. R., E. M. Marzluff, J. A. Townsend, W. C. Resager, and M. T. Marty, "Native Mass Spectrometry of Antimicrobial Peptides in Lipid Nanodiscs Elucidates Complex Assembly.", Anal Chem, vol. 91, issue 14, pp. 9284-9291, 2019 07 16. PMCID: PMC6635019 PMID: 31251560
Kostelic, M. M., A. M. Ryan, D. J. Reid, J. M. Noun, and M. T. Marty, "Expanding the Types of Lipids Amenable to Native Mass Spectrometry of Lipoprotein Complexes.", J Am Soc Mass Spectrom, vol. 30, issue 8, pp. 1416-1425, 2019 Aug. PMCID: PMC6675625 PMID: 30972726
Keener, J. E., D. Evan Zambrano, G. Zhang, C. K. Zak, D. J. Reid, B. S. Deodhar, J. E. Pemberton, J. S. Prell, and M. T. Marty, "Chemical additives enable native mass spectrometry measurement of membrane protein oligomeric state within intact nanodiscs.", J Am Chem Soc, 2018 Dec 26. PMID: 30586296
Reid, D. J., J. E. Keener, A. P. Wheeler, D. Evan Zambrano, J. M. Diesing, M. Reinhardt-Szyba, A. Makarov, and M. T. Marty, "Engineering Nanodisc Scaffold Proteins for Native Mass Spectrometry.", Anal Chem, vol. 89, issue 21, pp. 11189-11192, 2017 Nov 07. PMID: 29048874
Marty, M. T., K. Kuan Hoi, and C. V. Robinson, "Interfacing Membrane Mimetics with Mass Spectrometry.", Acc Chem Res, vol. 49, issue 11, pp. 2459-2467, 2016 11 15. PMCID: PMC5328410 PMID: 27736086