Marlys H Witte, MD

Professor, Surgery

lymph@arizona.edu

Links

Department Profile

NCBI Bibliography

Graduate of Barnard College, NYU School of Medicine, Internal Medicine Residency, UNC and Bellevue Hospital, Internal Medicine. Faculty: Washington University SOM and University of Arizona, Department of Surgery, 1969-present (Professor); Director, Student Research Programs, UA College of Medicine, 1982-present. Mentored hundreds of students supported by NIH multi-institute training grants since 1982 to develop diverse research workforce pipelines. “Women in Medical Academia” in mid-1970's and service reflect a long-standing commitment to leadership training, equity, diversity, and disadvantaged populations. Educational activities have an overlying theme of “medical ignorance” – “what we know we don’t know, don’t know we don’t know, and think we know but don’t,” aiming to nurture “curiosity”.

Cancer Focus

Lymphatic spread of cancer, lymphangiogenesis, benign and malignant lymphatic tumors; IBD and colon cancer; cancer and cancer treatment related lymphedema; lymphvascular genetics/genotype phenotype correlations; next generation lymphatic imaging. Co-organization of biennial International Congresses of Lymphology and Lymphatic and Cancer Spread Through the Lymphatic System/Cancer Metastasis biennial Conference.

Research Program Role

Cancer Prevention and Control Program

Display Name

Marlys H Witte, MD

Publications

Role of Lymphatic Deficiency in the Pathogenesis and Progression of Inflammatory Bowel Disease to Colorectal Cancer in an Experimental Mouse Model.

Daley SK, Witte MH, Washington J, Bernas M, Kiela P, Thorn J, Tanoue N, Alexander JS. 2019. Role of Lymphatic Deficiency in the Pathogenesis and Progression of Inflammatory Bowel Disease to Colorectal Cancer in an Experimental Mouse Model. Inflamm Bowel Dis. 25:1919–1926. doi:10.1093/ibd/izz112.

Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions.

Dellinger MT, Witte MH. 2018. Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions. Clin Exp Metastasis. 35:419–424. doi:10.1007/s10585-018-9907-9.

Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice.

Munger SJ, Geng X, Srinivasan RS, Witte MH, Paul DL, Simon AM. 2016. Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice. Dev Biol. 412:173–90. doi:10.1016/j.ydbio.2016.02.033.

Characterization of TCP-1 probes for molecular imaging of colon cancer.

Liu Z, Gray BD, Barber C, Bernas M, Cai M, Furenlid LR, Rouse A, Patel C, Banerjee B, Liang R, et al. 2016. Characterization of TCP-1 probes for molecular imaging of colon cancer. J Control Release. 239:223–30. doi:10.1016/j.jconrel.2016.08.033.

Overlapping biomarkers, pathways, processes and syndromes in lymphatic development, growth and neoplasia.

Witte MH, Dellinger MT, Papendieck CM, Boccardo F. 2012. Overlapping biomarkers, pathways, processes and syndromes in lymphatic development, growth and neoplasia. Clin Exp Metastasis. 29:707–27. doi:10.1007/s10585-012-9493-1.