Marlys H Witte, MD
Cancer Prevention and Control Program
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Professor, Surgery
Biography
Graduate of Barnard College, NYU School of Medicine, Internal Medicine Residency, UNC and Bellevue Hospital, Internal Medicine. Faculty: Washington University SOM and University of Arizona, Department of Surgery, 1969-present (Professor); Director, Student Research Programs, UA College of Medicine, 1982-present. Mentored hundreds of students supported by NIH multi-institute training grants since 1982 to develop diverse research workforce pipelines. “Women in Medical Academia” in mid-1970's and service reflect a long-standing commitment to leadership training, equity, diversity, and disadvantaged populations. Educational activities have an overlying theme of “medical ignorance” – “what we know we don’t know, don’t know we don’t know, and think we know but don’t,” aiming to nurture “curiosity”.
Cancer Focus
Lymphatic spread of cancer, lymphangiogenesis, benign and malignant lymphatic tumors; IBD and colon cancer; cancer and cancer treatment related lymphedema; lymphvascular genetics/genotype phenotype correlations; next generation lymphatic imaging. Co-organization of biennial International Congresses of Lymphology and Lymphatic and Cancer Spread Through the Lymphatic System/Cancer Metastasis biennial Conference.
Selected Publications
S. K. Daley, Witte, M. H., Washington, J., Bernas, M., Kiela, P., Thorn, J., Tanoue, N., and J Alexander, S., “Role of Lymphatic Deficiency in the Pathogenesis and Progression of Inflammatory Bowel Disease to Colorectal Cancer in an Experimental Mouse Model.”, Inflamm Bowel Dis, vol. 25, no. 12, pp. 1919-1926, 2019. PMCID: PMC6855278 PMID: 31173626
M. T. Dellinger and Witte, M. H., “Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions.”, Clin Exp Metastasis, vol. 35, no. 5-6, pp. 419-424, 2018. PMID: 29808352
S. J. Munger, Geng, X., R Srinivasan, S., Witte, M. H., Paul, D. L., and Simon, A. M., “Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice.”, Dev Biol, vol. 412, no. 2, pp. 173-90, 2016. PMCID: PMC4826804 PMID: 26953188
F. Becker, Potepalov, S., Shehzahdi, R., Bernas, M., Witte, M., Abreo, F., Traylor, J., Orr, W. A., Tsunoda, I., and Alexander, J. Steven, “Downregulation of FoxC2 Increased Susceptibility to Experimental Colitis: Influence of Lymphatic Drainage Function?”, Inflamm Bowel Dis, vol. 21, no. 6, pp. 1282-96, 2015. PMCID: PMC4437831 PMID: 25822012
M. H. Witte, Dellinger, M. T., Papendieck, C. M., and Boccardo, F., “Overlapping biomarkers, pathways, processes and syndromes in lymphatic development, growth and neoplasia.”, Clin Exp Metastasis, vol. 29, no. 7, pp. 707-27, 2012. PMID: 22798218