Dr. Moore has focused her program of research on the impact of central nervous system (CNS)-directed treatment for pediatric acute lymphoblastic leukemia (ALL) and brain tumors on cognitive outcomes and on mechanisms of tissue injury. She has conducted animal and cell culture studies to gain understanding about the mechanisms of treatment related injury and gene expression changes associated with chemotherapy. She and her research team developed and tested an intervention that improved academic math abilities and quality of life for children receiving CNS treatment for acute lymphoblastic leukemia (ALL). Her current work focuses on oxidative stress and apoptosis as mechanisms of chemotherapy-induced CNS injury.