Joyce A Schroeder, PhD

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Department Head, Molecular & Cellular Biology
Biography
1998: UNC-CH, Microbiology and Immunology, PhD
2001: Postdoct, Mayo Clinic Scottsdale
2002: Assistant Professor, MCB
2003-2007: Director, Experimental Mouse Shared Service
2002: Comprehensive Member, Arizona Cancer Center
2004: Member, BIO5 Institute
2008: Associate Professor, MCB
2010-2013: Co-Leader, Program in Cancer Biology and Genetics,
2011-present: Chief Scientific Officer, Arizona Cancer Therapeutics, LLC.
2013: Professor, MCB
2016: Director, Metastatic Breast Cancer Initiative
2017: Department Head, MCB
Cancer Focus
My laboratory investigates the Epidermal Growth Factor Receptor in transformation and metastasis. We focus on the alterations in receptor trafficking, signal transduction and non-canonical activities such as nuclear translocation and gene regulation that occur during cancer progression. Based on these studies, we have developed peptide-based therapeutics for cancer that block protein-protein interactions between EGFR and MUC1, as well as peptides that promote the multimerization of inactive ErbB receptors. We are now focused on the development of these peptide-based therapeutics for clinical applications, as well as investigating the mechanisms of alternative trafficking of ErbB receptors as a driver of transformation and metastasis.
Selected Publications
Maisel, S. A., D. Broka, B. Atwell, T. Bunch, R. Kupp, S. K. Singh, S. Mehta, and J. Schroeder, "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer.", J Transl Med, vol. 17, issue 1, pp. 201, 2019 06 18. PMCID: PMC6582486 PMID: 31215437
Maisel, S., D. Broka, and J. Schroeder, "Intravesicular epidermal growth factor receptor subject to retrograde trafficking drives epidermal growth factor-dependent migration.", Oncotarget, vol. 9, issue 5, pp. 6463-6477, 2018 Jan 19. PMCID: PMC5814225 PMID: 29464085
Greenwood, E., S. Maisel, D. Ebertz, A. Russ, R. Pandey, and J. Schroeder, "Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.", Oncotarget, vol. 7, issue 38, pp. 60776-60792, 2016 Sep 20. PMCID: PMC5308616 PMID: 27542214
Hart, M. R., H-Y. Su, D. Broka, A. Goverdhan, and J. A. Schroeder, "Inactive ERBB receptors cooperate with reactive oxygen species to suppress cancer progression.", Mol Ther, vol. 21, issue 11, pp. 1996-2007, 2013 Nov. PMCID: PMC3831044 PMID: 24081029
Horm, T. M., B. G. Bitler, D. M. Broka, J. M. Louderbough, and J. A. Schroeder, "MUC1 drives c-Met-dependent migration and scattering.", Mol Cancer Res, vol. 10, issue 12, pp. 1544-54, 2012 Dec. PMCID: PMC3528822 PMID: 23193156
Bitler, B. G., A. Goverdhan, and J. A. Schroeder, "MUC1 regulates nuclear localization and function of the epidermal growth factor receptor.", J Cell Sci, vol. 123, issue Pt 10, pp. 1716-23, 2010 May 15. PMCID: PMC2864713 PMID: 20406885