Joe G Garcia, MD

Professor, Medicine

skipgarcia@arizona.edu

Links

Department Profile

NCBI Bibliography

Biography

Joe G. N. "Skip" Garcia, MD, is the University of Arizona endowed Merlin K. DuVal MD Professor of Medicine, founder/CEO of Aqualung Therapeutics, and an elected member of the Institute of Medicine of the National Academies. Dr. Garcia is a leading authority on the genetic basis of lung disease with emphasis on health disparities, particularly of the underserved minorities. He has nearly 400 peer-reviewed publications and has an expansive portfolio of NIH-sponsored research and continues to direct large federally funded programs. Dr. Garcia is a passionate advocate for the training of physician-scientists and is an active supporter of minority medical and science students.

Cancer Focus

Dr. Garcia is internationally recognized for his genetic-based research on lung disease and for development of novel therapies for critically ill patients with acute inflammatory lung disease.

Display Name

Joe G Garcia, MD

Publications

Cohesive cancer invasion of the biophysical barrier of smooth muscle.

Harryman WL, Marr KD, Hernandez-Cortes D, Nagle RB, Garcia JGN, Cress AE. 2021. Cohesive cancer invasion of the biophysical barrier of smooth muscle. Cancer Metastasis Rev. 40:205–219. doi:10.1007/s10555-020-09950-2.

Role of secreted extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in prostate cancer progression: Novel biomarker and therapeutic target.

Sun BL, Sun X, Casanova N, Garcia AN, Oita R, Algotar AM, Camp SM, Hernon VR, Gregory T, Cress AE, et al. 2020. Role of secreted extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in prostate cancer progression: Novel biomarker and therapeutic target. EBioMedicine. 61:103059. doi:10.1016/j.ebiom.2020.103059.

Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell-Cell Biophysical Properties in Prostate Cancer.

Rubenstein CS, Gard JMC, Wang M, McGrath JE, Ingabire N, Hinton JP, Marr KD, Simpson SJ, Nagle RB, Miranti CK, et al. 2019. Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell-Cell Biophysical Properties in Prostate Cancer. Cancer Res. 79:4703–4714. doi:10.1158/0008-5472.CAN-19-0868.

Integrin α6β4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions.

Wang M, Hinton JP, Gard JMC, Garcia JGN, Knudsen BS, Nagle RB, Cress AE. 2019. Integrin α6β4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions. Mol Biol Cell. 30:838–850. doi:10.1091/mbc.E18-10-0652.

Tissue ACE phenotyping in lung cancer.

Danilov SM, Metzger R, Klieser E, Sotlar K, Trakht IN, Garcia JGN. 2019. Tissue ACE phenotyping in lung cancer. PLoS One. 14:e0226553. doi:10.1371/journal.pone.0226553.

Single nucleotide polymorphisms in the MYLKP1 pseudogene are associated with increased colon cancer risk in African Americans.

Lynn H, Sun X, Ayshiev D, Siegler JH, Rizzo AN, Karnes JH, Gonzales Garay M, Wang T, Casanova N, Camp SM, et al. 2018. Single nucleotide polymorphisms in the MYLKP1 pseudogene are associated with increased colon cancer risk in African Americans. PLoS One. 13:e0200916. doi:10.1371/journal.pone.0200916.

The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting...

Brown RV, Wang T, Chappeta VR, Wu G, Onel B, Chawla R, Quijada H, Camp SM, Chiang ET, Lassiter QR, et al. 2017. The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting. J Am Chem Soc. 139:7456–7475. doi:10.1021/jacs.6b10028.