Dr. Lu obtained his Ph.D. at the University of Pittsburgh in 2014 and then performed postdoctoral training on nanomedicine and tumor immunology at the University of Chicago and UCLA. He joined the University of Arizona as an Assistant Professor of Pharmaceutical Sciences in 2019. His research has been supported by the NIH/NIGMS Maximizing Investigators' Research Award (MIRA) (R35), the NIH/NCI R01, Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation Faculty Starter Grant in Drug Delivery, and the State of Arizona's Technology and Research Initiative Fund (TRIF)/BIO5 Institute as well as The Southwest Environmental Health Sciences Center (SWEHSC). Dr. Lu serves as the Director of the Pharmaceutics and Pharmacokinetics Track at the R. Ken Coit College of Pharmacy and the Associate Editor for Frontiers in Medical Technology: Nano-Based Drug Delivery.
Dr. Lu’s lab strives to develop innovative, safe, and efficacious nanotherapeutics at the interface of drug delivery, synthetic chemistry, molecular pharmaceutics, nanoengineering, and tumor immunology to address the pressing unmet needs in colorectal cancer, pancreatic cancer, breast cancer, melanoma, and lymphoma.
Wang Z, Li W, Park J, Gonzalez KMarie, Scott AJames, Lu J. "Camptothesome elicits immunogenic cell death to boost colorectal cancer immune checkpoint blockade." J Control Release. 2022. PMID: 35926754, 2022.
Wang Z, Cordova LEstrella, Chalasani P, Lu J. "Camptothesome Potentiates PD-L1 Immune Checkpoint Blockade for Improved Metastatic Triple-Negative Breast Cancer Immunochemotherapy." Mol Pharm. 2022;19(12):4665-4674. PMID: 36413426 , 2022.
Wang Z, Little N, Chen J, et al. "Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy." Nat Nanotechnol. 2021. PMID: 34385682 , 2021.
Lu J, Liu X, Liao Y-P, et al. "Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression." Nat Commun. 2017;8(1):1811. PMCID: PMC5703845 PMID: 29180759, 2017.
Lu J, Liu C, Wang P, et al. "The self-assembling camptothecin-tocopherol prodrug: An effective approach for formulating camptothecin." Biomaterials. 2015;62:176-87. PMCID: PMC4470812 PMID: 26057133, 2015.