Jessica A Martinez, PhD
Cancer Prevention and Control Program
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Analytical Chemistry Shared Resource
Biography
Dr. Martinez completed a BS in 2005 from Hillsdale College, Hillsdale, MI. At the University of Arizona, she completed an MS in Nutritional Science in 2007 and a PhD in Nutritional Sciences in 2010. She was an R25T Postdoctoral Fellow in Cancer Prevention and Control from 2011 – 2014 at UACC. Her training has been in the context of early phase clinical trials to understand the mechanisms of putative cancer chemopreventive agents, including resveratrol, limonene, green tea polyphenols, ursodeoxycholic acid, aspirin and selenium. These trials have primarily been in breast, but also colorectal, lung and esophageal cancers. She has been an Assistant Research Professor in Nutritional Sciences since 2015.
Cancer Focus
Dr. Martinez’ research focuses on early phase clinical development of cancer preventive agents and on modulating intermediate biomarkers of cancer risk contained in tissues and biofluids, including the metabolites, cytokines, proteins and metabolome. Of particular interest are oxylipins from arachidonic acid metabolism and bile acids. She is currently co-investigator on cancer prevention clinical trials to investigate the roles of metformin and sulindac in breast cancer prevention, of side effects of selenium in colorectal cancer prevention, and of limonene in obese Hispanic males. Additionally, she is co-PI of a pilot study to determine blood and imaging-based biomarkers of AIMSS in breast cancer patients.
Selected Publications
Martinez, J. A., J. Yang, B. C. Wertheim, D. J. Roe, A. Schriewer, P. Lance, D. S. Alberts, B. D. Hammock, and P. A. Thompson, "Celecoxib use and circulating oxylipins in a colon polyp prevention trial.", PLoS One, vol. 13, issue 4, pp. e0196398, 2018. PMCID: PMC5919576 PMID: 29698447
Martinez, J. A., B. C. Wertheim, C. A. Thomson, J. W. Bea, R. Wallace, M. Allison, L. Snetselaar, Z. Chen, R. Nassir, and P. A. Thompson, "Physical Activity Modifies the Association between Dietary Protein and Lean Mass of Postmenopausal Women.", J Acad Nutr Diet, vol. 117, issue 2, pp. 192-203.e1, 2017 02. PMCID: PMC5276713 PMID: 27914915
Martinez, J. A., P. Chalasani, C. A. Thomson, D. Roe, M. Altbach, J-P. Galons, A. Stopeck, P. A. Thompson, D. Evelyn Villa-Guillen, and H-H. Sherry Chow, "Phase II study of metformin for reduction of obesity-associated breast cancer risk: a randomized controlled trial protocol.", BMC Cancer, vol. 16, pp. 500, 2016 07 19. PMCID: PMC4950218 PMID: 27430256
Miller, J. A., K. Pappan, P. A. Thompson, E. J. Want, A. P. Siskos, H. C. Keun, J. Wulff, C. Hu, J. E. Lang, and H-H. Sherry Chow, "Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention.", Cancer Prev Res (Phila), vol. 8, issue 1, pp. 86-93, 2015 Jan. PMCID: PMC4289656 PMID: 25388013
Tredwell, G. D., J. A. Miller, H-H. Sherry Chow, P. A. Thompson, and H. C. Keun, "Metabolomic characterization of nipple aspirate fluid by (1)H NMR spectroscopy and GC-MS.", J Proteome Res, vol. 13, issue 2, pp. 883-9, 2014 Feb 07. PMCID: PMC4423791 PMID: 24364541