Gregory C Rogers, PhD
Cancer Biology Program
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Associate Professor, Cellular and Molecular Medicine
Associate Department Head, Faculty Development, Cellular and Molecular Medicine
Associate Professor, Molecular and Cellular Biology
Associate Professor, BIO5 Institute
Associate Professor, Cancer Biology GIDP
Associate Professor, Genetics GIDP
Biography
BA Biology, University of Rochester
PhD Cell and Developmental Biology, University of California, Davis
Postdoctoral Researcher, Albert Einstein College of Medicine
Postdoctoral Researcher, University of North Carolina, Chapel Hill
Cancer Focus
My lab is interested in the molecular mechanisms cells use to maintain genomic integrity. This is medically relevant because genomic instability is a hallmark of cancer. Specifically, we study centrosome biogenesis and function by focusing on the master-regulators characterizing Polo and Polo-like kinase 4 signaling pathways. Notably, centrosome copy number is unstable in cancer cells, leading to chromosome instability and tumorigenesis. The mechanisms that control centrosome copy number and how they are deregulated in cancer are unclear.
Selected Publications
Boese, C. J., J. Nye, D. W. Buster, T. A. McLamarrah, A. E. Byrnes, K. C. Slep, N. M. Rusan, and G. C. Rogers, "Asterless is a Polo-like kinase 4 substrate that both activates and inhibits kinase activity depending on its phosphorylation state.", Mol Biol Cell, vol. 29, issue 23, pp. 2874-2886, 2018 Nov 15. PMCID: PMC6249866 PMID: 30256714
McLamarrah, T. A., D. W. Buster, B. J. Galletta, C. J. Boese, J. M. Ryniawec, N. Ann Hollingsworth, A. E. Byrnes, C. W. Brownlee, K. C. Slep, N. M. Rusan, et al., "An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly.", J Cell Biol, vol. 217, issue 4, pp. 1217-1231, 2018 Apr 02. PMCID: PMC5881488 PMID: 29496738
Klebba, J. E., B. J. Galletta, J. Nye, K. M. Plevock, D. W. Buster, N. A. Hollingsworth, K. C. Slep, N. M. Rusan, and G. C. Rogers, "Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability.", J Cell Biol, vol. 208, issue 4, pp. 401-14, 2015 Feb 16. PMCID: PMC4332252 PMID: 25688134
Klebba, J. E., D. W. Buster, T. A. McLamarrah, N. M. Rusan, and G. C. Rogers, "Autoinhibition and relief mechanism for Polo-like kinase 4.", Proc Natl Acad Sci U S A, vol. 112, issue 7, pp. E657-66, 2015 Feb 17. PMCID: PMC4343128 PMID: 25646492