My lab is interested in the molecular mechanisms cells use to maintain genomic integrity. This is medically relevant because genomic instability is a hallmark of cancer. Specifically, we study centrosome biogenesis and function by focusing on the master-regulators characterizing Polo and Polo-like kinase 4 signaling pathways. Notably, centrosome copy number is unstable in cancer cells, leading to chromosome instability and tumorigenesis. The mechanisms that control centrosome copy number and how they are deregulated in cancer are unclear.