My laboratory studies the fundamental biology of aging. Age is the primary risk factor for the most prevalent diseases in our society, including cancer. By understanding and targeting the molecular processes that drive aging, we aim to extend healthy human lifespan and treat or prevent broad categories of age-associated disease simultaneously. Through a combination of systems and comparative genetics, we identified the kynurenine metabolic pathway as a promising intervention target to slow aging. We have ongoing projects examining the impact of kynurenine pathway interventions on longevity, cancer onset during normal aging, and cancer progression once established.