Georg T Wondrak, PhD

wondrak@pharmacy.arizona.edu

Links

Based on my international professional training [Swiss Federal Institute of Technology (ETH Zurich), Universidad Autónoma de Madrid (UAM), Technical University Berlin (TUB), University of Kentucky (UK)] my research group at the College of Pharmacy and the University of Arizona Cancer Center is well positioned to pursue the discovery of novel redox-directed experimental and investigational cancer therapeutics. From 2016-2018, I have served as President leading the American Society for Photobiology (ASP).

Cancer Focus

Redox Drug Discovery Targeting Skin Cancer and Solar Photodamage:
My NIH-funded drug discovery research program examines the pathological role of oxidative and proteotoxic stress in solar photodamage and skin cancer (melanoma and non melanoma), focusing on pharmacological modulation of cellular stress response pathways.

Research Program Role

Clinical and Translational Oncology Program

Display Name
Georg T Wondrak, PhD

Publications

Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice.

Blohm-Mangone K, Burkett NB, Tahsin S, Myrdal PB, Aodah A, Ho B, Janda J, McComas M, Saboda K, Roe DJ, et al. 2018. Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice. Cancer Prev Res (Phila). 11:265–278. doi:10.1158/1940-6207.CAPR-17-0349.

Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin.

Janda J, Burkett NB, Blohm-Mangone K, Huang V, Curiel-Lewandrowski C, Alberts DS, Petricoin EF, Calvert VS, Einspahr J, Dong Z, et al. 2016. Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin. Photochem Photobiol. 92:816–825. doi:10.1111/php.12659.

The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes.

Park SL, Justiniano R, Williams JD, Cabello CM, Qiao S, Wondrak GT. 2015. The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes. J Invest Dermatol. 135:1649–1658. doi:10.1038/jid.2014.503.

Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde.

Long M, Tao S, de la Vega MR, Jiang T, Wen Q, Park SL, Zhang DD, Wondrak GT. 2015. Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. Cancer Prev Res (Phila). 8:444–54. doi:10.1158/1940-6207.CAPR-14-0359.

The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.

Davis AL, Qiao S, Lesson JL, de la Vega MR, Park SL, Seanez CM, Gokhale V, Cabello CM, Wondrak GT. 2015. The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. J Biol Chem. 290:1623–38. doi:10.1074/jbc.M114.592626.

Georg T Wondrak, PhD

Links

Cancer Focus

Display Name
Georg T Wondrak, PhD

Publications

Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice.

TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis.

Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin.

A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin.

Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin.

The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes.

Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde.

The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.

Georg T Wondrak, PhD

Links

Cancer Focus

Display NameGeorg T Wondrak, PhD

Publications

Display Name
Georg T Wondrak, PhD