Felicia D Goodrum Sterling, PhD
Cancer Biology Program
-
Professor, Immunobiology
Biography
Felicia Goodrum graduated with her Ph.D. from Wake Forest University and then trained as a postdoctoral fellow with Thomas Shenk at Princeton University where she was a Leukemia and Lymphoma Society Fellow and Special Fellow. In 2006, Dr. Goodrum joined the faculty at the University of Arizona and BIO5 Institute in Tucson. Dr. Goodrum’s work throughout her career has focused on complex interaction between DNA viruses and their host. She is currently focused on the mechanisms of human cytomegalovirus latency and persistence. Her laboratory has identified viral determinants of infection important for latency and reactivation as well as the host factors and pathways targeted by these viral factors.
Cancer Focus
Viruses cause at least 10-20% of all cancers. Yet, viruses have also been powerful tools for the discovery of oncogenes, tumor suppressors and basic cellular processes. Herpesviruses are no exception. Our laboratory focusses on the beta-herpesvirus, human cytomegalovirus or CMV. CMV latently infects up to 99% of the population worldwide. CMV can reactivate to cause life-threatening disease in leukemia and lymphoma patients undergoing stem cell transplantation. While CMV is not known to cause cancer, oncomodulatory properties have emerged. Our research focuses on understanding how CMV modulates host trafficking and receptor tyrosine kinase signaling (e.g., EGFR) and DNA damage repair pathways and the impact of this viral regulation on host cell biology and the maintenance of latency or reactivation from latency.
Selected Publications
Crawford, L. B., R. Tempel, D. N. Streblow, A. D. Yurochko, F. D. Goodrum, J. A. Nelson, and P. Caposio, "Human Cytomegalovirus Infection Suppresses CD34 Progenitor Cell Engraftment in Humanized Mice.", Microorganisms, vol. 8, issue 4, 2020 Apr 06. PMCID: PMC7232458 PMID: 32268565
Collins-McMillen, D., M. Rak, J. C. Buehler, S. Igarashi-Hayes, J. P. Kamil, N. J. Moorman, and F. Goodrum, "Alternative promoters drive human cytomegalovirus reactivation from latency.", Proc Natl Acad Sci U S A, vol. 116, issue 35, pp. 17492-17497, 2019 08 27. PMCID: PMC6717278 PMID: 31409717
Buehler, J., E. Carpenter, S. Zeltzer, S. Igarashi, M. Rak, I. Mikell, J. A. Nelson, and F. Goodrum, "Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency.", PLoS Pathog, vol. 15, issue 11, pp. e1008037, 2019 11. PMCID: PMC6855412 PMID: 31725811
Zeltzer, S., C. A. Zeltzer, S. Igarashi, J. Wilson, J. G. Donaldson, and F. Goodrum, "Virus Control of Trafficking from Sorting Endosomes.", MBio, vol. 9, issue 4, 2018 07 24. PMCID: PMC6058287 PMID: 30042195
Rak, M. A., J. Buehler, S. Zeltzer, J. Reitsma, B. Molina, S. Terhune, and F. Goodrum, "Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.", J Virol, vol. 92, issue 20, 2018 Oct 15. PMCID: PMC6158428 PMID: 30089695
Caviness, K., F. Bughio, L. B. Crawford, D. N. Streblow, J. A. Nelson, P. Caposio, and F. Goodrum, "Complex Interplay of the UL136 Isoforms Balances Cytomegalovirus Replication and Latency.", MBio, vol. 7, issue 2, pp. e01986, 2016 Mar 01. PMCID: PMC4810493 PMID: 26933055
Buehler, J., S. Zeltzer, J. Reitsma, A. Petrucelli, M. Umashankar, M. Rak, P. Zagallo, J. Schroeder, S. Terhune, and F. Goodrum, "Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication.", PLoS Pathog, vol. 12, issue 5, pp. e1005655, 2016 05. PMCID: PMC4878804 PMID: 27218650
Goodrum, F., "Human Cytomegalovirus Latency: Approaching the Gordian Knot.", Annu Rev Virol, vol. 3, issue 1, pp. 333-357, 2016 09 29. PMCID: PMC5514425 PMID: 27501258