Emmanuel Katsanis, MD
I am a Professor of Pediatrics, Medicine, Immunobiology, Pathology and a member of the University of Arizona Cancer Center, Steele Children’s Research Center and the Bio5 Institute. I combine my expertise in the laboratory and the clinical arenas as the Director of the Hematopoietic Cellular Therapy and Transplant Program (adult and pediatric) and Division Chief of Pediatric Hematology/Oncology. I have 30+ years of research experience in the field of tumor and transplant immunology.
More recently my work has focused on immunomodulation with bendamustine following haploidentical-BMT. Additionally, my laboratory is studying pre-transplant modulation of host cells by selective agents and their effects on immune reconstitution, graft versus host disease and graft versus tumor effects. I designed and initiated an ongoing phase I/Ib clinical trial in haploidentical bone marrow transplantation based from our published preclinical work.
Katsanis, E., L. N. Sapp, N. Varner, S. Koza, B. Stea, and Y. Zeng, "Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide/Bendamustine in Pediatric and Young Adult Patients with Hematologic Malignancies.", Biol Blood Marrow Transplant, vol. 24, issue 10, pp. 2034-2039, 2018 Oct. PMID: 29908231
Stokes, J., E. A. Hoffman, M. S. Molina, J. Eremija, N. Larmonier, Y. Zeng, and E. Katsanis, "Bendamustine with Total Body Irradiation Limits Murine Graft-versus-Host Disease in Part Through Effects on Myeloid-Derived Suppressor Cells.", Biol Blood Marrow Transplant, 2018 Oct 13. PMID: 30326280
Zeng, Y., S. Hahn, J. Stokes, E. A. Hoffman, M. Schmelz, M. Proytcheva, J. Chernoff, and E. Katsanis, "Pak2 regulates myeloid-derived suppressor cell development in mice.", Blood Adv, vol. 1, issue 22, pp. 1923-1933, 2017 Oct 10. PMCID: PMC5728145 PMID: 29296839
Stokes, J., E. A. Hoffman, Y. Zeng, N. Larmonier, and E. Katsanis, "Post-transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation.", Br J Haematol, vol. 174, issue 1, pp. 102-16, 2016 07. PMCID: PMC4917459 PMID: 27030315
Zeng, Y., J. Stokes, S. Hahn, E. Hoffman, and E. Katsanis, "Activated MHC-mismatched T helper-1 lymphocyte infusion enhances GvL with limited GvHD.", Bone Marrow Transplant, vol. 49, issue 8, pp. 1076-83, 2014 Aug. PMID: 24777185