Deepta Bhattacharya, PhD

Professor, Immunobiology

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Deepta Bhattacharya received his PhD from the University of California, Berkeley, studying the role of the NF-kB transcription factor in survival and B cell class switching. For his postdoctoral fellowship, he trained at Stanford University, studying the cell biology of hematopoietic stem cells and their differentiated progeny. In 2008, he began his own lab at Washington University in St. Louis, first as an Assistant Professor and then as a tenured Associate Professor. Dr. Bhattacharya returned in 2017 to his birthplace of Tucson to join the Department of Immunobiology, where his lab continues to study both stem cells and antibody responses to infections and vaccines.

Cancer Focus

Stem cells and lymphocytes of the immune lineage are both inherently programmable systems, designed to cope with a broad diversity of demands. Research in the Bhattacharya Lab merges the fields of stem cell biology and immunology to understand the basic biology of lymphocyte development, survival pathways that promote both plasma cell longevity and malignancies, and to develop creative translational strategies to combat cancer.

Research Program Role

Cancer Biology Program

Display Name

Deepta Bhattacharya, PhD

Publications

Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.

Wong R, Belk JA, Govero J, Uhrlaub JL, Reinartz D, Zhao H, Errico JM, D’Souza L, Ripperger TJ, Nikolich-Žugich J, et al. 2020. Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses. Immunity. 53:1078–1094.e7. doi:10.1016/j.immuni.2020.09.001.

Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T-Cell-Induced, and Infectious Colitis in Mice.

Jamwal DR, Laubitz D, Harrison CA, Figliuolo da Paz V, Cox CM, Wong R, Midura-Kiela M, Gurney MA, Besselsen DG, Setty P, et al. 2020. Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T-Cell-Induced, and Infectious Colitis in Mice. Gastroenterology. 159:1342–1356.e6. doi:10.1053/j.gastro.2020.06.049.

Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity.

Ripperger TJ, Uhrlaub JL, Watanabe M, Wong R, Castaneda Y, Pizzato HA, Thompson MR, Bradshaw C, Weinkauf CC, Bime C, et al. 2020. Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity. Immunity. 53:925–933.e4. doi:10.1016/j.immuni.2020.10.004.

Metabolic and Transcriptional Modules Independently Diversify Plasma Cell Lifespan and Function.

Lam WY, Jash A, Yao C-H, D’Souza L, Wong R, Nunley RM, Meares GP, Patti GJ, Bhattacharya D. 2018. Metabolic and Transcriptional Modules Independently Diversify Plasma Cell Lifespan and Function. Cell Rep. 24:2479–2492.e6. doi:10.1016/j.celrep.2018.07.084.

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells.

Lam WY, Becker AM, Kennerly KM, Wong R, Curtis JD, Llufrio EM, McCommis KS, Fahrmann J, Pizzato HA, Nunley RM, et al. 2016. Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells. Immunity. 45:60–73. doi:10.1016/j.immuni.2016.06.011.

ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.

Jash A, Wang Y, Weisel FJ, Scharer CD, Boss JM, Shlomchik MJ, Bhattacharya D. 2016. ZBTB32 Restricts the Duration of Memory B Cell Recall Responses. J Immunol. 197:1159–68. doi:10.4049/jimmunol.1600882.

Deepta Bhattacharya, PhD

Links

Cancer Focus

Display Name Deepta Bhattacharya, PhD

Publications

Display Name

Deepta Bhattacharya, PhD