Deepta Bhattacharya, PhD
Cancer Biology Program
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Professor, Immunobiology
Biography
Deepta Bhattacharya received his PhD from the University of California, Berkeley, studying the role of the NF-kB transcription factor in survival and B cell class switching. For his postdoctoral fellowship, he trained at Stanford University, studying the cell biology of hematopoietic stem cells and their differentiated progeny. In 2008, he began his own lab at Washington University in St. Louis, first as an Assistant Professor and then as a tenured Associate Professor. Dr. Bhattacharya returned in 2017 to his birthplace of Tucson to join the Department of Immunobiology, where his lab continues to study both stem cells and antibody responses to infections and vaccines.
Cancer Focus
Stem cells and lymphocytes of the immune lineage are both inherently programmable systems, designed to cope with a broad diversity of demands. Research in the Bhattacharya Lab merges the fields of stem cell biology and immunology to understand the basic biology of lymphocyte development, survival pathways that promote both plasma cell longevity and malignancies, and to develop creative translational strategies to combat cancer.
Selected Publications
T. J. Ripperger, Uhrlaub, J. L., Watanabe, M., Wong, R., Castaneda, Y., Pizzato, H. A., Thompson, M. R., Bradshaw, C., Weinkauf, C. C., Bime, C., Erickson, H. L., Knox, K., Bixby, B., Parthasarathy, S., Chaudhary, S., Natt, B., Cristan, E., Aini, T. El, Rischard, F., Campion, J., Chopra, M., Insel, M., Sam, A., Knepler, J. L., Capaldi, A. P., Spier, C. M., Dake, M. D., Edwards, T., Kaplan, M. E., Scott, S. Jain, Hypes, C., Mosier, J., Harris, D. T., LaFleur, B. J., Sprissler, R., Nikolich-Žugich, J., and Bhattacharya, D., “Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity.”, Immunity, vol. 53, no. 5, pp. 925-933.e4, 2020. PMCID: PMC7554472 PMID: 33129373
R. Wong, Belk, J. A., Govero, J., Uhrlaub, J. L., Reinartz, D., Zhao, H., Errico, J. M., D'Souza, L., Ripperger, T. J., Nikolich-Žugich, J., Shlomchik, M. J., Satpathy, A. T., Fremont, D. H., Diamond, M. S., and Bhattacharya, D., “Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.”, Immunity, vol. 53, no. 5, pp. 1078-1094.e7, 2020. PMCID: PMC7677180 PMID: 33010224
W. Y. Lam, Jash, A., Yao, C. - H., D'Souza, L., Wong, R., Nunley, R. M., Meares, G. P., Patti, G. J., and Bhattacharya, D., “Metabolic and Transcriptional Modules Independently Diversify Plasma Cell Lifespan and Function.”, Cell Rep, vol. 24, no. 9, pp. 2479-2492.e6, 2018. PMCID: PMC6172041 PMID: 30157439
W. Y. Lam, Becker, A. M., Kennerly, K. M., Wong, R., Curtis, J. D., Llufrio, E. M., McCommis, K. S., Fahrmann, J., Pizzato, H. A., Nunley, R. M., Lee, J., Wolfgang, M. J., Patti, G. J., Finck, B. N., Pearce, E. L., and Bhattacharya, D., “Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells.”, Immunity, vol. 45, no. 1, pp. 60-73, 2016. PMCID: PMC4956536 PMID: 27396958
A. Jash, Wang, Y., Weisel, F. J., Scharer, C. D., Boss, J. M., Shlomchik, M. J., and Bhattacharya, D., “ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.”, J Immunol, vol. 197, no. 4, pp. 1159-68, 2016. PMCID: PMC4975986 PMID: 27357154