My laboratory investigates the signaling mechanisms controlling cell fate of the gut. We address fundamental questions in cancer biology: How do cells identify, measure, and respond to each other and to their environment? What signals control the renewal and regeneration of epithelial tissues? How do these signals malfunction in colorectal cancer? Our goal is to uncover an underlying circuit theory behind these behaviors – a set of predictive principles revealing how complex functionality arises from simpler biological components. We focus on kinase networks that regulate healthy tissues and are dis-regulated in cancer. Through quantitative imaging and drug discovery, we are finding ways to understand and repair these networks.