Cindy K. Miranti, PhD

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Professor, Cellular and Molecular Medicine
Professor, BIO5 Institute
Chair, Cancer Biology Graduate Interdisciplinary Program
Biography
Cindy K. Miranti earned her B.Sc. in Microbiology from Southern Illinois University and Master’s in Microbiology from Colorado State University. She obtained her Ph.D in Biochemistry from Harvard Medical School. She completed her postdoctoral training at ARIAD Pharmaceuticals and Harvard Medical School. She joined the Van Andel Research Institute as an Assistant Professor and then Associate Professor. In 2016, she moved to University of Arizona as Professor of Cellular and Molecular Medicine. She is Leader of the Prostate Cancer Research Group, and Chair of the Cancer Biology Graduate Interdisciplinary Program.
Cancer Focus
My laboratory investigates how cell adhesion through integrins, controls the interactions of tumor cells with the surrounding tissues, and how they influence prostate cancer development, drug resistance, and bone metastasis. Our research is focused in three primary areas: 1) developing in vitro and in vivo models that recapitulate human disease based on clinical pathology, 2) identifying pathways and molecules that could serve as clinical markers and/or therapeutic targets, and 3) defining the genetic events involved in normal prostate and bone development to determine how they are disrupted by cancer.
Selected Publications
Miranti, C. K., S. Moore, Y. Kim, V. Reddy Chappeta, K. Wu, B. De, V. Gokhale, L. H. Hurley, and E. M. Reyes-Reyes, "Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex.", Oncotarget, vol. 11, issue 19, pp. 1758-1776, 2020 May 12. PMCID: PMC7233804 PMID: 32477465
Nollet, E. A., M. Cardó-Vila, S. S. Ganguly, J. D. Tran, V. V. Schulz, A. Cress, E. Corey, and C. K. Miranti, "Androgen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer.", Oncogene, vol. 39, issue 31, pp. 5390-5404, 2020 Jul. PMCID: PMC7395876 PMID: 32565538
Ganguly, S. S., G. Hostetter, L. Tang, S. B. Frank, K. Saboda, R. Mehra, L. Wang, X. Li, E. T. Keller, and C. K. Miranti, "Notch3 promotes prostate cancer-induced bone lesion development via MMP-3.", Oncogene, vol. 39, issue 1, pp. 204-218, 2020 01. PMCID: PMC6938550 PMID: 31467432
Jiang, L., F. Ivich, S. Tahsin, M. Tran, S. B. Frank, C. K. Miranti, and Y. Zohar, "Human stroma and epithelium co-culture in a microfluidic model of a human prostate gland.", Biomicrofluidics, vol. 13, issue 6, pp. 064116, 2019 Nov. PMCID: PMC6867939 PMID: 31768202
Toth, R. K., J. D. Tran, M. T. Muldong, E. A. Nollet, V. V. Schulz, C. C. Jensen, L. A. Hazlehurst, E. Corey, D. Durden, C. Jamieson, et al., "Hypoxia-induced PIM kinase and laminin-activated integrin α6 mediate resistance to PI3K inhibitors in bone-metastatic CRPC.", Am J Clin Exp Urol, vol. 7, issue 4, pp. 297-312, 2019. PMCID: PMC6734039 PMID: 31511835
Bergsma, A., S. S. Ganguly, D. Dick, B. O. Williams, and C. K. Miranti, "Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis.", Bone, vol. 113, pp. 105-113, 2018 Aug. PMID: 29782939
Das, L., J. M. C. Gard, R. Prekeris, R. B. Nagle, C. Morrissey, B. S. Knudsen, C. K. Miranti, and A. E. Cress, "Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.", Mol Cancer Res, vol. 16, issue 8, pp. 1319-1331, 2018 Aug. PMID: 29759989
Frank, S. B., V. V. Schulz, and C. K. Miranti, "A streamlined method for the design and cloning of shRNAs into an optimized Dox-inducible lentiviral vector.", BMC Biotechnol, vol. 17, issue 1, pp. 24, 2017 02 28. PMCID: PMC5331646 PMID: 28245848
Berger, P. L., M. E. Winn, and C. K. Miranti, "Miz1, a Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation.", Prostate, vol. 77, issue 1, pp. 49-59, 2017 01. PMID: 27527891
Frank, S. B., P. L. Berger, M. Ljungman, and C. K. Miranti, "Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC.", J Cell Sci, vol. 130, issue 11, pp. 1952-1964, 2017 Jun 01. PMID: 28446540
Tesfay, L., V. V. Schulz, S. B. Frank, L. E. Lamb, and C. K. Miranti, "Receptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1.", Mol Biol Cell, vol. 27, issue 15, pp. 2493-504, 2016 08 01. PMCID: PMC4966988 PMID: 27307589