Chi Zhou, PhD

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Assistant Professor, Physiology
Biography
Chi Zhou is an Assistant Professor at the School of Animal and Comparative Biomedical Sciences at the University of Arizona. She earned her Ph.D. in Animal Science with an emphasis in Reproductive Physiology from the University of Alberta, CANADA. She then completed postdoctoral training at the Perinatal Research Labs, Department of Obstetrics and Gynecology, University of Wisconsin-Madison. Her research aims to elucidate the cellular and molecular mechanisms underlying fetal endothelial dysfunction that associate with complicated pregnancies.
Cancer Focus
Our lab focuses on the molecular mechanisms underlying the fetal sex-specific dysregulation of fetal endothelial function (such as disturbed angiogenesis and responses to TNF-α) in complicated pregnancies, and the maternal obesity-associated fetal endothelial dysfunction and future health risks of the offspring. Our research utilizing multiple model systems including human placenta tissue, human cell models, and in vivo animal models. Results from our research will provide new insights into discovering novel biomarkers or therapeutic targets for sex-specific endothelial dysregulation in children born to complicated pregnancies.
Selected Publications
Zhou, C., Q-Y. Zou, Y-Z. Jiang, and J. Zheng, "Role of oxygen in fetoplacental endothelial responses: hypoxia, physiological normoxia, or hyperoxia?", Am J Physiol Cell Physiol, vol. 318, issue 5, pp. C943-C953, 2020 05 01. PMCID: PMC7294327 PMID: 32267717
Li, Y., C. Zhou, W. Lei, K. Wang, and J. Zheng, "Roles of Aryl Hydrocarbon Receptor in Endothelial Angiogenic Responses†.", Biol Reprod, 2020 Jul 27. PMID: 32716482
Zhou, C., Q. Yan, Q-Y. Zou, X-Q. Zhong, C. T. Tyler, R. R. Magness, I. M. Bird, and J. Zheng, "Sexual Dimorphisms of Preeclampsia-Dysregulated Transcriptomic Profiles and Cell Function in Fetal Endothelial Cells.", Hypertension, vol. 74, issue 1, pp. 154-163, 2019 07. PMCID: PMC6561818 PMID: 31154903
Zou, Q-Y., Y-J. Zhao, H. Li, X-Z. Wang, A-X. Liu, X-Q. Zhong, Q. Yan, Y. Li, C. Zhou, and J. Zheng, "GNA11 differentially mediates fibroblast growth factor 2- and vascular endothelial growth factor A-induced cellular responses in human fetoplacental endothelial cells.", J Physiol, vol. 596, issue 12, pp. 2333-2344, 2018 06. PMCID: PMC6002203 PMID: 29659033
Zhou, C., Q-Y. Zou, H. Li, R-F. Wang, A-X. Liu, R. R. Magness, and J. Zheng, "Preeclampsia Downregulates MicroRNAs in Fetal Endothelial Cells: Roles of miR-29a/c-3p in Endothelial Function.", J Clin Endocrinol Metab, vol. 102, issue 9, pp. 3470-3479, 2017 09 01. PMCID: PMC5587062 PMID: 28911139