Carlos Caulin, PhD

Cancer Biology Program, Research Member

Biography

Carlos Caulin received his Ph.D from the Universidad Autonoma (Madrid, Spain), studying alterations in epidermal differentiation during skin carcinogenesis. He then completed his postdoctoral training at The Burnham Institute (San Diego, CA) investigating mechanisms of epithelial apoptosis, and later moved to Baylor College of Medicine (Houston, TX) to study the function of oncogenes involved in squamous cell carcinoma development. He then joined the Department of Head and Neck Surgery-Research at MD Anderson Cancer Center (Huston, TX) as Assistant Professor. In 2018 he moved to the University of Arizona in Tucson as Associate Professor in the Department of Otolaryngology - Head & Neck Surgery and Director of Translational Head/Neck Cancer Research.

Cancer Focus

Our laboratory is interested in studying genetic alterations involved in head and neck malignancies. Specifically, we study the oncogenic functions of p53 gain-of-function mutations, their contribution to head and neck cancer development and their role in the response to immunotherapies. We are also studying the oncogenic activities of the Myb transcription factor in salivary adenoid cystic carcinoma. Our primary approach is to generate immunocompetent genetically engineered mouse models that recapitulate these oncogenic events and the associated malignancies. Cross-species analyses between mouse and human tumors, and preclinical studies are conducted to identify key mechanisms that promote cancer development and resistance to therapy, and to identify strategies to overcome these processes.