Rui Chang, PhD

Associate Professor, Neurology

Biography

Rui Chang earned his B.Sc. in Electrical Engineering from Beijing University of Technology and M.Sc in Communication Engineering from Technical University of Munich (TUM), Germany and obtained Ph.D in Computer Science with focus on machine learning from TUM. He completed postdoctoral training in computational biology at University of California, San Diego. He joined Icahn School of Medicine at Mount Sinai as an Assistant Professor in 2011. In 2018, he moved to University of Arizona as Associate Professor in the department of Neurology and the associated director for computational systems biology in The Center of Innovations in Brain Sciences. He is PI of Computational Biology lab in neurodegenerative diseases and cancer.

Cancer Focus

My researches in cancer investigate the molecular mechanisms of immune response in various tumors and interactions between tumor and microenvironment especially immune systems by leveraging computational models. The final goal of my research is to discover novel and adjuvants immunotherapy for cancer.

Research Program Role

Clinical and Translational Oncology Program

Display Name

Rui Chang, PhD

Publications

Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness.

Carcamo-Orive I, Henrion MYR, Zhu K, Beckmann ND, Cundiff P, Moein S, Zhang Z, Alamprese M, D’Souza SL, Wabitsch M, et al. 2020. Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness. PLoS Comput Biol. 16:e1008491. doi:10.1371/journal.pcbi.1008491.

Validation of Melanoma Immune Profile (MIP), a Prognostic Immune Gene Prediction Score for Stage II-III Melanoma.

Gartrell RD, Marks DK, Rizk EM, Bogardus M, Gérard CL, Barker LW, Fu Y, Esancy CL, Li G, Ji J, et al. 2019. Validation of Melanoma Immune Profile (MIP), a Prognostic Immune Gene Prediction Score for Stage II-III Melanoma. Clin Cancer Res. 25:2494–2502. doi:10.1158/1078-0432.CCR-18-2847.

The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target.

Petyuk VA, Chang R, Ramirez-Restrepo M, Beckmann ND, Henrion MYR, Piehowski PD, Zhu K, Wang S, Clarke J, Huentelman MJ, et al. 2018. The human brainome: network analysis identifies HSPA2 as a novel Alzheimer&rsquo;s disease target. Brain. 141:2721–2739. doi:10.1093/brain/awy215.

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.

Carcamo-Orive I, Hoffman GE, Cundiff P, Beckmann ND, D’Souza SL, Knowles JW, Patel A, Papatsenko D, Abbasi F, Reaven GM, et al. 2017. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity. Cell Stem Cell. 20:518–532.e9. doi:10.1016/j.stem.2016.11.005.

Dissection of immune gene networks in primary melanoma tumors critical for antitumor surveillance of patients with stage II-III resectable disease.

Sivendran S, Chang R, Pham L, Phelps RG, Harcharik ST, Hall LD, Bernardo SG, Moskalenko MM, Sivendran M, Fu Y, et al. 2014. Dissection of immune gene networks in primary melanoma tumors critical for antitumor surveillance of patients with stage II-III resectable disease. J Invest Dermatol. 134:2202–2211. doi:10.1038/jid.2014.85.

Rui Chang, PhD

Biography

Cancer Focus

Display Name Rui Chang, PhD

Publications

Display Name

Rui Chang, PhD