New research uncovers gene impacts of PFAS exposure in firefighters
A new paper provides evidence of how PFAS, often called “forever chemicals,” correspond to epigenetic changes that can lead to cancers, neurological disorders and autoimmune conditions.
Researchers at the University of Arizona Mel and Enid Zuckerman College of Public Health and the University of Arizona Comprehensive Cancer Center found that certain kinds of long-lasting chemicals firefighters are exposed to may affect the activity of genes linked to cancer and other diseases. The findings appear in the journal Environmental Research.
The study is among the first to connect common industrial chemicals called PFAS – per- and polyfluoroalkyl substances – to changes in microRNAs, or miRNAs, which are molecules that act as guardrails to help control gene expression.
PFAS are found in a wide range of products, including upholstery, insulation, electronics, cleaning products, fabrics, non-stick cookware – and firefighting foam and gear. Firefighters can be at higher risk for certain cancers, and exposure to toxic chemicals may be one reason why.
“Firefighters tend to have higher PFAS levels due to their occupational exposures,” said first author Melissa Furlong, PhD, an associate cancer center member and professor of environmental health sciences at the Zuckerman College of Public Health. “Gene activity can be affected by changes in the environment. We wanted to see the imprint of PFAS exposure on miRNAs and evaluate which ones might be associated with diseases.”