My lab is focused on understanding the complex biological mechanisms that allow cancer cells to thrive in the hypoxia (low oxygen). While hypoxia is toxic to normal cells, cancer cells take advantage of their ability to adapt to these harsh conditions and promote survival. For tumors grow and survive in hypoxia, it is essential that cancer cells activate signaling pathways that promote survival and angiogenesis. My lab uses complementary in vitro and in vivo models of cancer to identify and characterize novel signaling pathways involved in the adaptive response to hypoxia. We work closely with closely with clinical researchers to facilitate the translation of our findings to clinical application.