Donato F Romagnolo, PhD, MSc

Professor, Nutritional Sciences

donato@arizona.edu

Links

Department Profile

NCBI Bibliography

Donato Romagnolo, PhD, MSc. is Professor of Nutritional and Cancer Biology in the Department of Nutritional Sciences and a member of the Arizona Cancer Center (AZCC), Center for Toxicology, BIO5 Research Institute, and School of Comparative and Biomedical Sciences. He received his Bachelor of Science from the University of Padua, Italy, and Masters of Science and Doctoral degrees from Virginia Tech, Blacksburg, VA. He trained as a postdoctoral fellow at the National Institutes of Health, National Institutes of Health. At the University of Arizona, he teaches undergraduate Nutritional Biology and graduate Bioenergetic courses. He is Director of the University of Arizona Study Abroad Program on Mediterranean Diet and Health.

Cancer Focus

Dr. Romagnolo’s research focuses on; (i) mechanisms of epigenetic regulation of breast cancer genes by dietary and environmental xenobiotics; 2) role of dietary bioactive food components in the etiology and prevention of breast cancer and inflammation; 3) impact of dietary components on epigenetic regulation of genes involved in bile acids homeostasis and influences on inflammatory bowel diseases and intestinal tumorigenesis.

Research Program Role

Cancer Biology Program

Display Name

Donato F Romagnolo, PhD, MSc

Publications

A -Driven Transgene Modulates Enterohepatic Bile Acid Homeostasis and Response to an -6-Enriched High-Fat Diet.

Wren SN, Donovan MG, Selmin OI, Doetschman TC, Romagnolo DF. 2020. A -Driven Transgene Modulates Enterohepatic Bile Acid Homeostasis and Response to an -6-Enriched High-Fat Diet. Int J Mol Sci. 21. doi:10.3390/ijms21217829.

Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer.

Selmin OI, Donovan MG, Stillwater BJ, Neumayer L, Romagnolo DF. 2020. Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer. Front Nutr. 7:159. doi:10.3389/fnut.2020.00159.

Epigenetic Activation of by Genistein In Vivo and Triple Negative Breast Cancer Cells Linked to Antagonism toward Aryl Hydrocarbon Receptor.

Donovan MG, Selmin OI, Doetschman TC, Romagnolo DF. 2019. Epigenetic Activation of by Genistein In Vivo and Triple Negative Breast Cancer Cells Linked to Antagonism toward Aryl Hydrocarbon Receptor. Nutrients. 11. doi:10.3390/nu11112559.

-6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer.

Romagnolo DF, Donovan MG, Doetschman TC, Selmin OI. 2019. -6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer. Nutrients. 11. doi:10.3390/nu11010171.

Genistein Prevents CpG Methylation and Proliferation in Human Breast Cancer Cells with Activated Aromatic Hydrocarbon Receptor.

Romagnolo DF, Donovan MG, Papoutsis AJ, Doetschman TC, Selmin OI. 2017. Genistein Prevents CpG Methylation and Proliferation in Human Breast Cancer Cells with Activated Aromatic Hydrocarbon Receptor. Curr Dev Nutr. 1:e000562. doi:10.3945/cdn.117.000562.

Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis.

Romagnolo DF, Papoutsis AJ, Laukaitis C, Selmin OI. 2015. Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis. BMC Cancer. 15:1026. doi:10.1186/s12885-015-2044-9.