2015
Downregulation of FoxC2 Increased Susceptibility to Experimental Colitis: Influence of Lymphatic Drainage Function?
Becker F, Potepalov S, Shehzahdi R, Bernas M, Witte M, Abreo F, Traylor J, Orr WA, Tsunoda I, Alexander JS. 2015. Downregulation of FoxC2 Increased Susceptibility to Experimental Colitis: Influence of Lymphatic Drainage Function?. Inflamm Bowel Dis. 21:1282–96. doi:10.1097/MIB.0000000000000371.
Dynamic changes of RNA-sequencing expression for precision medicine: N-of-1-pathways Mahalanobis distance within pathways of single subjects predicts breast cancer survival.
Schissler AG, Gardeux V, Li Q, Achour I, Li H, Piegorsch WW, Lussier YA. 2015. Dynamic changes of RNA-sequencing expression for precision medicine: N-of-1-pathways Mahalanobis distance within pathways of single subjects predicts breast cancer survival. Bioinformatics. 31:i293–302. doi:10.1093/bioinformatics/btv253.
Metformin in breast cancer - an evolving mystery.
Camacho L, Dasgupta A, Jiralerspong S. 2015. Metformin in breast cancer - an evolving mystery. Breast Cancer Res. 17:88. doi:10.1186/s13058-015-0598-8.
Short term exposure to di-n-butyl phthalate (DBP) disrupts ovarian function in young CD-1 mice.
Sen N, Liu X, Craig ZR. 2015. Short term exposure to di-n-butyl phthalate (DBP) disrupts ovarian function in young CD-1 mice. Reprod Toxicol. 53:15–22. doi:10.1016/j.reprotox.2015.02.012.
Targeting Survivin Inhibits Renal Cell Carcinoma Progression and Enhances the Activity of Temsirolimus.
Carew JS, Espitia CM, Zhao W, Mita MM, Mita AC, Nawrocki ST. 2015. Targeting Survivin Inhibits Renal Cell Carcinoma Progression and Enhances the Activity of Temsirolimus. Mol Cancer Ther. 14:1404–13. doi:10.1158/1535-7163.MCT-14-1036.
The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes.
Park SL, Justiniano R, Williams JD, Cabello CM, Qiao S, Wondrak GT. 2015. The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes. J Invest Dermatol. 135:1649–1658. doi:10.1038/jid.2014.503.
Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
Duca FA, Côté CD, Rasmussen BA, Zadeh-Tahmasebi M, Rutter GA, Filippi BM, Lam TKT. 2015. Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat Med. 21:506–11. doi:10.1038/nm.3787.
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma.
Postow MA, Chesney J, Pavlick AC, Robert C, Grossmann K, McDermott D, Linette GP, Meyer N, Giguere JK, Agarwala SS, et al. 2015. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med. 372:2006–17. doi:10.1056/NEJMoa1414428.
Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde.
Long M, Tao S, de la Vega MR, Jiang T, Wen Q, Park SL, Zhang DD, Wondrak GT. 2015. Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. Cancer Prev Res (Phila). 8:444–54. doi:10.1158/1940-6207.CAPR-14-0359.
Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.
Côté CD, Rasmussen BA, Duca FA, Zadeh-Tahmasebi M, Baur JA, Daljeet M, Breen DM, Filippi BM, Lam TKT. 2015. Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. Nat Med. 21:498–505. doi:10.1038/nm.3821.
The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase.
Song L-N, Silva J, Koller A, Rosenthal A, Chen EI, Gelmann EP. 2015. The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase. Mol Cancer Res. 13:913–22. doi:10.1158/1541-7786.MCR-14-0680.
A DNA/HDAC dual-targeting drug CY190602 with significantly enhanced anticancer potency.
Liu C, Ding H, Li X, Pallasch CP, Hong L, Guo D, Chen Y, Wang D, Wang W, Wang Y, et al. 2015. A DNA/HDAC dual-targeting drug CY190602 with significantly enhanced anticancer potency. EMBO Mol Med. 7:438–49. doi:10.15252/emmm.201404580.
Apatinib: a promising oral antiangiogenic agent in the treatment of multiple solid tumors.
Scott AJ, Messersmith WA, Jimeno A. 2015. Apatinib: a promising oral antiangiogenic agent in the treatment of multiple solid tumors. Drugs Today (Barc). 51:223–9. doi:10.1358/dot.2015.51.4.2320599.
Transgenerational inheritance of diet-induced genome rearrangements in Drosophila.
Aldrich JC, Maggert KA. 2015. Transgenerational inheritance of diet-induced genome rearrangements in Drosophila. PLoS Genet. 11:e1005148. doi:10.1371/journal.pgen.1005148.
A single-center experience and review of the literature: 64 cases of phyllodes tumors to better understand risk factors and disease management.
Lightner AL, Shurell E, Dawson N, Omidvar Y, Foster N. 2015. A single-center experience and review of the literature: 64 cases of phyllodes tumors to better understand risk factors and disease management. Am Surg. 81:309–15.
Increase in oxidative stress as measured by cerebrospinal fluid lipid peroxidation during treatment for childhood acute lymphoblastic leukemia.
Moore IMK, Gundy P, Pasvogel A, Montgomery DW, Taylor OA, Koerner KM, McCarthy K, Hockenberry MJ. 2015. Increase in oxidative stress as measured by cerebrospinal fluid lipid peroxidation during treatment for childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 37:e86–93. doi:10.1097/MPH.0000000000000258.
Autoinhibition and relief mechanism for Polo-like kinase 4.
Klebba JE, Buster DW, McLamarrah TA, Rusan NM, Rogers GC. 2015. Autoinhibition and relief mechanism for Polo-like kinase 4. Proc Natl Acad Sci U S A. 112:E657–66. doi:10.1073/pnas.1417967112.
Epigenomics: Roadmap for regulation.
Romanoski CE, Glass CK, Stunnenberg HG, Wilson L, Almouzni G. 2015. Epigenomics: Roadmap for regulation. Nature. 518:314–6. doi:10.1038/518314a.
Formulation and characterization of inhalable magnetic nanocomposite microparticles (MnMs) for targeted pulmonary delivery via spray drying.
Stocke NA, Meenach SA, Arnold SM, Mansour HM, Hilt JZ. 2015. Formulation and characterization of inhalable magnetic nanocomposite microparticles (MnMs) for targeted pulmonary delivery via spray drying. Int J Pharm. 479:320–8. doi:10.1016/j.ijpharm.2014.12.050.
Trigonal scaffolds for multivalent targeting of melanocortin receptors.
Elshan NGRD, Jayasundera T, Anglin BL, Weber CS, Lynch RM, Mash EA. 2015. Trigonal scaffolds for multivalent targeting of melanocortin receptors. Org Biomol Chem. 13:1778–91. doi:10.1039/c4ob02094d.
Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability.
Klebba JE, Galletta BJ, Nye J, Plevock KM, Buster DW, Hollingsworth NA, Slep KC, Rusan NM, Rogers GC. 2015. Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability. J Cell Biol. 208:401–14. doi:10.1083/jcb.201410105.
*equal contributors (2015) Differential expression of cell cycle regulators in Cdk5-dependent neuroendocrine thyroid cancer tumorigenesis. Oncotarget, 6:12080-93.
Pozo K, Hillman A, Agustiyn A, Plattner F, Raezani S, Singh T, Sun X, Minna J, Cote G, Chen H, et al. 2015. *equal contributors (2015) Differential expression of cell cycle regulators in Cdk5-dependent neuroendocrine thyroid cancer tumorigenesis. Oncotarget, 6:12080-93.
A phase II/III randomized study to compare the efficacy and safety of rigosertib plus gemcitabine versus gemcitabine alone in patients with previously untreated metastatic pancreatic cancer.
O’Neil BH, Scott AJ, Ma WW, Cohen SJ, Leichman L, Aisner DL, Menter AR, Tejani MA, Cho JK, Granfortuna J, et al. 2015. A phase II/III randomized study to compare the efficacy and safety of rigosertib plus gemcitabine versus gemcitabine alone in patients with previously untreated metastatic pancreatic cancer. Ann Oncol. 26:1923–9. doi:10.1093/annonc/mdv264.
EFFECT OF SELENIUM SUPPLEMENTATION ON PROTEOMIC SERUM BIOMARKERS IN ELDERLY MEN.
Algotar AM, Behnejad R, Singh P, Thompson PA, Hsu CH, Stratton SP. 2015. EFFECT OF SELENIUM SUPPLEMENTATION ON PROTEOMIC SERUM BIOMARKERS IN ELDERLY MEN. J Frailty Aging. 4:107–10. doi:10.14283/jfa.2015.48.
GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.
Thorne CA, Wichaidit C, Coster AD, Posner BA, Wu LF, Altschuler SJ. 2015. GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 11:58–63. doi:10.1038/nchembio.1690.