Jeffrey J. Pu, MD, PhD

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Associate Professor, Medicine (Tenured)
Director of Adult HCTT Program
Chief of Leukemia and BMF Diseases Section
Biography
Dr. Pu received Ph.D. in Developmental Molecular Cell Biology from New York Medical College and MD from Shanghai Jiao Tong University School of Medicine. He completed his Medicine Residency at Mount Sinai School of Medicine. He then completed a NIH-supported experimental hematology fellowship at pioneer Dr. Colvin M. Redman’s laboratory and a clinical transfusion medicine/blood banking fellowship at the LFK Research Institute of New York Blood Center. He eventually completed Hematology/Oncology fellowship supported by NIHT32 training grant at Sidney Kimmel Comprehensive Cancer Center of Johns Hopkins University. Dr. Pu is certified as an expert of BMF diseases and a preferred hematologist consultant by the Aplastic Anemia & MDS International Foundation.
Cancer Focus
Dr. Pu’s research interests include hematopoietic mechanism of hematological malignant disease progression, stem cell biology, biomarker translational research, cellular therapy, early phase clinical trials, and HCTT outcome-research. He is credited for first in the world identified and cloned hPD-1 gene and its immune modulating function; identified Kell blood gene-group expression pattern in early hematopoiesis and the cause of Kell alloimmune-induced severe fetal anemia; determined that PNH clone size of 25% as the golden diagnostic standard to predict the risk of significant hemolysis in aplastic anemia (AA); identified the origins of hypocellular myelodysplastic syndromes (MDS) and AA; and identified PIGN gene as a CIN suppressor in MDS progression/leukemic transformation.
Selected Publications
Pu, J. J., J. Poulose, J. Malysz, J. Zhu, J. C. Fanburg-Smith, D. F. Claxton, and M. G. Bayerl, "Impact of ruxolitinib on myelofibrosis patients post allogeneic stem cell transplant-a pilot study.", Br J Haematol, vol. 186, issue 5, pp. e130-e133, 2019 09. PMCID: PMC6706301 PMID: 31115038
Teye, E. K., A. Sido, P. Xin, N. K. Finnberg, P. Gokare, Y. I. Kawasawa, A. C. Salzberg, S. Shimko, M. Bayerl, C. W Ehmann, et al., "PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features.", Oncotarget, vol. 8, issue 18, pp. 29887-29905, 2017 May 02. PMCID: PMC5444711 PMID: 28187452
Pu, J. J., R. Hu, G. L. Mukhina, H. E. Carraway, M. A. McDevitt, and R. A. Brodsky, "The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells.", Haematologica, vol. 97, issue 8, pp. 1225-33, 2012 Aug. PMCID: PMC3409821 PMID: 22315493
Pu, J. J., G. Mukhina, H. Wang, W. J. Savage, and R. A. Brodsky, "Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia.", Eur J Haematol, vol. 87, issue 1, pp. 37-45, 2011 Jul. PMCID: PMC3120909 PMID: 21447004
Finger, L. R., J. Pu, R. Wasserman, R. Vibhakar, E. Louie, R. R. Hardy, P. D. Burrows, and L. G. Billips, "The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors.", Gene, vol. 197, issue 1-2, pp. 177-87, 1997 Sep 15. PMID: 9332365